MORPHOLOGY STUDY OF PLAI PATCH BY THE SCANNING ELECTRON MICROSCOPE. PART I: CHITOSAN AND HYDROXYPROPYLMETHYLCELLULOSE BLENDS

Authors

  • Jirapornchai Suksaeree Faculty of Pharmacy and Sino-Thai Traditional Medicine Research Center (Cooperation between Rangsit University, Harbin Institute of Technology, and Heilongjiang University of Chinese Medicine), Rangsit University, Pathum Thani 12000, Thailand.
  • Chaowalit Monton Faculty of Pharmacy and Sino-Thai Traditional Medicine Research Center (Cooperation between Rangsit University, Harbin Institute of Technology, and Heilongjiang University of Chinese Medicine), Rangsit University, Pathum Thani 12000, Thailand.
  • Tossaton Charoonratana Faculty of Pharmacy and Sino-Thai Traditional Medicine Research Center (Cooperation between Rangsit University, Harbin Institute of Technology, and Heilongjiang University of Chinese Medicine), Rangsit University, Pathum Thani 12000, Thailand.

Keywords:

Morphology study, Plai, Patches, HPMC

Abstract

Objective: The compound D or (E)-4-(3', 4'-dimethoxyphenyl)-but-3-en-1-ol is the main active chemical constituent in Zingiber cassumunar Roxb. (Plai) used for the treatment of asthma, for muscle and joint pain. This research aimed to study the surface morphology of Plai patch after in vitro release study of compound D. This patch made from polymer blends consisted of chitosan and hydroxypropylmethyl cellulose using glycerine as plasticizer.

Methods: The crude Plai oil was dissolved in absolute ethanol and homogeneously mixed into the polymer blends solution consisted of chitosan, hydroxypropylmethyl cellulose, and glycerine, and then dried in hot air oven to produce the Plai patch. The Plai patch was placed into Franz cell diffusion apparatus for 24 hours. After that, the Plai patch was photographed by scanning electron microscope (SEM) to study the morphology of this patch after compound D release.

Results: The morphology of the Plai patch after the release of compound D was visualized by SEM. The morphology of Plai patch made from polymer blends between chitosan, hydroxypropylmethyl cellulose, and glycerine had various numbers of pores, suggesting that the release of compound D occur mainly in patch surfaces and its might diffused through the matrix pores due to the active compound solubilization in the receptor medium, isotonic phosphate buffer pH 7.4: ethanol = 8:2.

Conclusion: When the Plai patch absorbed the moisture and fluid from receptor medium, the Plai patch might swell and release the compound D, main active compound in Plai from this patch. This might contributed the pore in Plai patch.

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References

Adrian CW, Editor D. Topical and transdermal formulations, in Transdermal and Topical Drug Press:Illinois. p. 169-94 p.

Ghosh TK, Abraham W, Jasti BR, Jasti TK, R. B, C. CR. Transdermal and topical drug delivery systems, in Theory and Practice of Contemporary Pharmaceutics, Editors. Florida. p. 423-55 p.

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Suksaeree J, Madaka F, Monton C, Sakunpak A, Chusut T, Charoonratana T, et al. Method validation of (E)-4-(3',4'-dimethoxyphenyl)-but-3-en-1-ol in Zingiber cassumunar Roxb. with different extraction techniques Int Pharm Sci 2014;6(3):295-8.

Suksaeree J, Monton C, Charoenchai L, Madaka F, Chusut T, J. Determination of (E)-4-(3', 4'-dimethoxyphenyl)-but-3-en-1-ol content in Zingiber cassumunar Roxb. Plai patches Int Pharm Sci 2014;6(5):253-6.

Suksaeree J, Monton C, Sakunpak A, Madaka F, Pichayakorn W, J. Physicochemical properties study of Plai patches for topical applications. Int Pharm Sci 2014;6(5):434-6.

Published

01-07-2014

How to Cite

Suksaeree, J., C. Monton, and T. Charoonratana. “MORPHOLOGY STUDY OF PLAI PATCH BY THE SCANNING ELECTRON MICROSCOPE. PART I: CHITOSAN AND HYDROXYPROPYLMETHYLCELLULOSE BLENDS”. International Journal of Pharmacy and Pharmaceutical Sciences, vol. 6, no. 7, July 2014, pp. 576-7, https://www.innovareacademics.in/journals/index.php/ijpps/article/view/1764.

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