GASTRIC ANTISECRETORY AND ANTIULCER PROPERTIES OF ETHANOLIC EXTRACTS OF LEAVES OF ANDROGRAPHYS PANICULATA

Authors

  • Pavan Kumar Sharma Department of Pharmaceutical Sciences, St. Joseph College of Pharmacy, Moinabad, Rangareddy District, JNTU, Andhra Pradesh, India, 500075
  • Joseph Peter Department of Pharmaceutical Sciences, St. Joseph College of Pharmacy, Moinabad, Rangareddy District, JNTU, Andhra Pradesh, India, 500075
  • Swapna M. Department of Pharmaceutical Sciences, St. Joseph College of Pharmacy, Moinabad, Rangareddy District, JNTU, Andhra Pradesh, India, 500075

Keywords:

A paniculata, Gastric secretion, Gastric ulcers, Cytoprotection, Gastric wall mucus

Abstract

Objective: To study the gastric anti-secretory and cytoprotective action of ethanolic extract of leaves of Andrographys paniculata.

Methods: Effect of ethanolic extract of leaves of A. paniculata gastro-antisecretory and cytoprotective activity was studied in vivo by using gastric wall mucus determination, hypothermic restraint stress-induced ulcers, idomethacin-induced gastric ulcers, reserpine-induced gastric ulcers and necrotizing agent-induced gastric ulcers (cytoprotection studies) methods.

Results: Ethanolic extract of leaves of A. paniculata produced a significant decrease in gastric secretion in pylorous ligated rats and a highly significant cytoprotective effect against 80% ethanol-0.6 M HCl, 0.2 M NaOH, and 25% NaCl-induced cytodestruction.

Conclusion: Pretreatment with the extract significantly prevented hypothermic stress-induced gastric wall mucus depletion. These findings suggest that a significant antisecretory and cytoprotective action A. paniculata can be responsible for its antiulcer activity.

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Published

01-07-2014

How to Cite

Sharma, P. K., J. Peter, and S. M. “GASTRIC ANTISECRETORY AND ANTIULCER PROPERTIES OF ETHANOLIC EXTRACTS OF LEAVES OF ANDROGRAPHYS PANICULATA”. International Journal of Pharmacy and Pharmaceutical Sciences, vol. 6, no. 7, July 2014, pp. 383-5, https://www.innovareacademics.in/journals/index.php/ijpps/article/view/1780.

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