ANTIINFLAMMATORY AND ANTIOXIDANT ACTIVITIES OF 2-AMINO-N-(SUBSTITUTED ALKYL) BENZOXAZOLE-5-CARBOXAMIDE DERIVATIVES

Authors

  • Aruna Devi Paralapalli University College of Pharmaceutical Sciences, Kakatiya university, Warangal 506009
  • Kishore University College of Pharmaceutical Sciences, Kakatiya university, Warangal 506009
  • Manasa Cidda University College of Pharmaceutical Sciences, Kakatiya university, Warangal 506009
  • Sarangapani Manda University College of Pharmaceutical Sciences, Kakatiya university, Warangal 506009

Keywords:

Benzoxazole, Synthesis, Antiinflammatory, Antioxidant

Abstract

Objective: In continuation of the work on Benzoxazoles present work deals with the synthesis,characterization and evaluation of 2-Amino-N-(substituted alkyl) benzoxazole-5- carboxamides for anti-inflammatory and antioxidant activities.

Methods: Synthetic methodology of benzoxazoles from 4-carbomethoxynitrophenol.Evaluation of compounds for anti-inflammatory activity by carragenean induced rat paw odema method and antioxidant activity by DPPH method.

Results: Among them compounds Vc(R=ethyl), Ve(R=propyl) and Vg (R=diisopropyl) V g (R=propyl) were found to be potent compounds. Compound Vf (R=isopropyl) showed comparatively more percentage of free radical scavenging activity with IC 50 of 4.65 when compared with the standard ascorbic acid.

Conclusion: Vf is considered to be the dual anti-inflammatory and antioxidant agent.

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Published

01-07-2014

How to Cite

Paralapalli, A. D., Kishore, M. Cidda, and S. Manda. “ANTIINFLAMMATORY AND ANTIOXIDANT ACTIVITIES OF 2-AMINO-N-(SUBSTITUTED ALKYL) BENZOXAZOLE-5-CARBOXAMIDE DERIVATIVES”. International Journal of Pharmacy and Pharmaceutical Sciences, vol. 6, no. 7, July 2014, pp. 311-4, https://www.innovareacademics.in/journals/index.php/ijpps/article/view/1787.

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