EFFECT OFSALIX TETRASPERMAROXBUGH ON FRUCTOSE INDUCED HYPERTENSION IN RATS
Keywords:NIBP, Antihypertensive, Fructose, Glibenclamide, Salix tetrasperma Roxburgh
Objective: The present study was designed to evaluate the effect of the ethanolic and aqueous extract of Salix tetrasperma Roxburgh on blood pressure by fructose induced hypertensive rats.
Methods: The Salix tetrasperma Roxburgh leaves were evaluated for antihypertensive potential by using fructoseâ€“induced hypertension model in Wister albino rats. The test animals were given high fructose (10%) diet for 21st days to induced hypertension. Subsequently, the 200 and 400 mg/kg/day (p. o.) doses of ethanolic and aqueous extracts of Salix tetrasperma leaves were administered to the different groups of hypertensive and normal animals. The hypertensive condition of the experimental animals was confirmed on 21st day by measuring systolic, diastolic and mean arterial pressure (SBP, DBP, MAP) using noninvasive BP (NIBP) system for rodents. The SBP, DBP, MAP were again recorded on day 0 d, 7th, 14th and 21st day of administration standard and test extracts. The normal control group of animals were given normal diet and administrated normal saline throughout the experiment.
Results: The both test extracts significantly reduced SBP, DBP and MAP significantly (P<0.05) lowered blood pressure effect in 0 d, 7th day at the dose of 200 and 400 mg/kg in fructose induced hypertensive rats. On 14thday the test extracts at the doses of 400 mg/kg significantly reduce only DBP and MAP. However, the treatment is continued for 21 d but no significant activity observed. The test extracts reveals that antihypertensive of Salix tetrasperma Roxburgh in dose dependent manner in hypertensive control rats.
Conclusion: These observations established the traditional claim and thus Salix tetrasperma Roxburgh could be a potent antihypertensive agent for use in future. The phyto constituents present in the test samples may be responsible for the hypotensive effect. However, further investigation is required to identify the active principles responsible for antihypertensive activity.
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