UV SPECTROPHOTOMETRIC METHOD DEVELOPMENT AND VALIDATION FOR THE QUANTITATIVE ESTIMATION OF SOLIFENACIN SUCCINATE IN TABLETS
Keywords:UV, Solifenacin succinate, Method development, Validation
Objective: To develop a simple and cheap UV spectrophotometric method for the quantitative estimation of Solifenacin succinate (5mg) in tablets and validate as per ICH guidelines.
Methods: The optimized method uses a solvent 100% triethylammonium phosphate buffer (pH 2.5) for the estimation of assay of Solifenacin succinate in tablets at a detection wavelength of 215 nm.
Results: The developed method resulted in Solifenacin succinate exhibiting linearity in the range 5-15Î¼g/ml. The precision is exemplified by relative standard deviation of 1.27%. Percentage Mean recovery was found to be in the range of 98â€102, during accuracy studies. The limit of detection (LOD) and limit of quantitiation (LOQ) were found to be 1.106mg/ml and 3.35mg/ml respectively.
Conclusion: A simple and a cheap UV spectrophotometric method was developed and validated for the quantitative estimation of Solifenacin succinate in tablets as per ICH guidelines and hence it can be used for the routine analysis in various pharmaceutical industries.
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