A SINGLE CASE REPORT ON HYPONATREMIA SEIZURE INDUCED BY ACETYLCHOLINESTERASE INHIBITORS

Authors

  • J. Shareef Department of Pharmacy Practice, NGSM Institute of Pharmaceutical Sciences, Mangaluru, Karnataka, India
  • J. Joseph Department of Pharmacy Practice, NGSM Institute of Pharmaceutical Sciences, Mangaluru, Karnataka, India
  • Adithi K. Department of General Medicine, K S Hegde Hospital, Mangaluru, Karnataka, India

DOI:

https://doi.org/10.22159/ijpps.2017v9i7.19057

Keywords:

Adverse drug reactions, Acetylcholinesterase inhibitors, Naranjo Algorithm, Severity level assessment

Abstract

Donepezil and memantine are the acetylcholinesterase inhibitors most commonly used in clinical practice for the management of mild-moderate dementia in Alzheimer's disease. Electrolyte abnormalities associated with the drugs are commonly encountered in daily clinical practice and often can lead to seizures. Hyponatremia is an uncommon adverse effects of acetylcholinesterase inhibitors. Here we present a case on hyponatremia seizure due to the syndrome of inappropriate antidiuretic hormone (SIADH) caused by the acetylcholinesterase inhibitor donepezil and memantine as other likely causes were ruled out by appropriate investigations. The causality assessment needed to be done according to Naranjo algorithm was found to be ‘probable' and the level of severity according to the Hartwig scale was ‘Level 5'.

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Published

01-07-2017

How to Cite

Shareef, J., J. Joseph, and A. K. “A SINGLE CASE REPORT ON HYPONATREMIA SEIZURE INDUCED BY ACETYLCHOLINESTERASE INHIBITORS”. International Journal of Pharmacy and Pharmaceutical Sciences, vol. 9, no. 7, July 2017, pp. 165-6, doi:10.22159/ijpps.2017v9i7.19057.

Issue

Vol 9, Issue 7, 2017

Section

Case Study(s)

Copyright (c) 2017 J. Shareef, J. Joseph, Adithi K.

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

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