ANTIMICROBIAL AND ANTI-INFLAMMATORY STUDIES ON SARGASSUM WIGHTII EXTRACTS
Keywords:Antimicrobial, Anti-inflammatory, Sargassum wightii
Objective: To evaluate the antimicrobial and anti-inflammatory effect of hexane, chloroform and ethanolic extract of Sargassum wightii.
Methods: Hexane, chlorofom and ethanolic extractions of these algae were done and evaluated for biological activity. Assay of antimicrobial activity was perfomed by disc diffusion method against various microorganisms. Assay of anti-inflammatory activity was performed in albino rats with paw edema, induced by Carrageenan.
Results: Chloroform and ethanol extracts exhibited antimicrobial activity against various microorganisms. All the extracts revealed anti-inflammatory activity, in which chloroform extract showed maximum activity in dose dependent manner.
Conclusions: Among the three different extracts tested, chloroform extract of S. wightii possess significant antimicrobial and anti-inflammatory activities. Further in-depth studies, could result in the development of a good antimicrobial and anti-inflammatory agent from this chloroform extract of S.wightii.
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