ORAL ADMINISTRATION OF THYMOQUINONE ATTENUATES BENZO (A) PYRENE INDUCED LUNG CARCINOGENESIS IN MALE SWISS ALBINO MICE

Authors

  • Gajendran Nithya Department of Medical Biochemistry, Dr. ALM PG Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai 600113, India
  • Revathi Mani Department of Medical Biochemistry, Dr. ALM PG Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai 600113, India
  • Dhanapal Sakthisekaran Department of Medical Biochemistry, Dr. ALM PG Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai 600113, India

Keywords:

Benzo(a)pyrene, Lung cancer, Thymoquinone, Heme indices, Membrane bound ATPases

Abstract

Objective: The present study has been designed to unravel the anticancer potential of thymoquinone against Benzo(a)pyrene induced lung cancer in male swiss albino mice. Thymoquinone (C10H12O20 )is a bioactive compound derived from the medicinal plant Nigella sativa. Thymoquinone (TQ) has been shown to exert anticancer effect on various cancer cell lines and there is no study on the efficacy of TQ on Benzo(a)pyrene [B(a)P] induced lung carcinogenesis in male swiss albino mice.

Methods: The changes in heme indices ( RBC, Hb, WBC, monocytes, lymphocytes and neutrophils), membrane bound ATPases (Na+/K+ ATPase, Mg2+ ATPase and Ca2+ ATPase) in control and experimental animals were analysed in serum and lung tissue homogenate.

Results: Lung cancer induced animals showed a considerably altered levels of heme indices with concomitant decreased levels of membrane bound ATPases in the lung tissue and erythrocyte membrane. Oral administration of TQ at a dose of 20mg/kg b.w brought back the levels of the biochemical parameters to near normal.

Conclusion: TQ supplementation restored the detrimental effects induced by B (a) P, indicating its anticancer potential in the treatment of experimental lung carcinogenesis.

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Published

01-07-2014

How to Cite

Nithya, G., R. Mani, and D. Sakthisekaran. “ORAL ADMINISTRATION OF THYMOQUINONE ATTENUATES BENZO (A) PYRENE INDUCED LUNG CARCINOGENESIS IN MALE SWISS ALBINO MICE”. International Journal of Pharmacy and Pharmaceutical Sciences, vol. 6, no. 7, July 2014, pp. 260-3, https://www.innovareacademics.in/journals/index.php/ijpps/article/view/2007.

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