• Beena Jose Department of Chemistry, Vimala College, Thrissur, Kerala, 680009, India
  • Alice Thomas Department of Statistics, Mercy College, Palakkad, Kerala, India.


Wrightia tinctoria, Antibacterial activity, Statistical analysis, Standard antibiotics, Drug formulation


Objective: Wrightia tinctoria has been extensively used in Folk medicine. It has been reported to have good analgesic, anti-inflammatory, anthelmintic, antiulcer, antidysentric, antidiabetic, anticancer, antipyretic activities and also effective in the treatment of psoriasis. The present investigation was undertaken to statistically evaluate the antimicrobial activity of the leaf and bark extracts of Wrightia tinctoria.

Methods: The antibacterial and antifungal activities of leaf coconut oil extracts (1, 4, 7 and 15 days exposure to sunlight), bark and leaf methanol, ethyl acetate, chloroform and petroleum ether extracts of Wrightia tinctoria (Apocynaceae) against nine pathogenic bacteria such as Bacillus cereus, Enterobacter faecalis, Salmonella paratyphi, Staphylococcus aureus, Escherichia coli, Proteus vulgaris, Klebsiella pneumoniae, Pseudomonas aeruginosa and Serratia marcescens and two fungi viz. Aspergillus niger and Penicillium chrysogenum were statistically analyzed so as to evaluate the medicinal potential of these plant extracts.

Results: Wrightia tinctoria leaf and bark methanol extracts were found to be potent extracts and their activity is quite comparable with the standard antibiotics such as tobramycin and gentamycin sulphate screened under similar conditions.

Conclusion: Methanol extracts of the leaves and bark of Wrightia tinctoria can be used as a potential external antiseptic and can be incorporated into drug formulations.


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How to Cite

Jose, B., and A. Thomas. “STATISTICAL ANALYSIS OF THE ANTIMICROBIAL ACTIVITY OF WRIGHTIA TINCTORIA LEAF AND BARK EXTRACTS”. International Journal of Pharmacy and Pharmaceutical Sciences, vol. 6, no. 7, July 2014, pp. 293-5,



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