PREPARATION AND EVALUATION OF ETHYLCELLULOSE MICROSPHERES PREPARED BY SOLVENT EVAPORATION TECHNIQUE

Authors

  • Hussain Mohammed Asif Blue Birds College of Pharmacy, Bheemaram, Hanamkonda-506015, Andhra Pradesh, India
  • Renukuntla Arun Kumar Blue Birds College of Pharmacy, Bheemaram, Hanamkonda-506015, Andhra Pradesh, India
  • T. Rama Rao Avanthi Institute of Pharmaceutical Sciences, Gunthapally (V), Hayathnagar- 501512, Ranga Reddy Dist, Andhra Pradesh, India.
  • Maimuna Anjum Blue Birds College of Pharmacy, Bheemaram, Hanamkonda-506015, Andhra Pradesh, India

Keywords:

Ethylcellulose microspheres, Solvent evaporation, Losartan

Abstract

Losartan is high specific angiotensin 2 type receptor antagonist with antihypertensive activity was formulated as microspheres by using Ethyl cellulose as carrier. These Ethyl cellulose microspheres were prepared by the solvent evaporation method. The prepared microspheres were subjected to various evaluation and in vitro release studies. Highest percentage of loading was obtained by increasing the amount of Losartan with respect to polymer. The particle sizes of the prepared microspheres were determined by optical microscopy and SEM analysis. The prepared microspheres had good spherical geometry with smooth surface as evidence by SEM. The in vitro release studies showed that Losartan microspheres of 1:5 ratios showed better sustained effect over a period of 12 hours.

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Published

01-07-2014

How to Cite

Asif, H. M., R. A. Kumar, T. R. Rao, and M. Anjum. “PREPARATION AND EVALUATION OF ETHYLCELLULOSE MICROSPHERES PREPARED BY SOLVENT EVAPORATION TECHNIQUE”. International Journal of Pharmacy and Pharmaceutical Sciences, vol. 6, no. 7, July 2014, pp. 264-6, https://www.innovareacademics.in/journals/index.php/ijpps/article/view/2045.

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