PREPARATION AND EVALUATION OF NILVADIPNE LIQUISOLID COMPACTS

Authors

  • Mohammed Asif Hussain Blue Birds College of Pharmacy, Bheemaram, Warangal, A.P, INDIA 506001
  • Manish Gorre Blue Birds College of Pharmacy, Bheemaram, Warangal, A.P, INDIA 506001
  • T. Rama Rao Avanthi Institute of Pharmaceutical Sciences, Gunthapally (V), Hayathnagar- 501512, Ranga Reddy Dist, Andhra Pradesh, India
  • Maimuna Anjum Blue Birds College of Pharmacy, Bheemaram, Warangal, A.P, INDIA 506001

Keywords:

Nilvadipine, PEG, PG, Avicel PH 102, Aerosil, Super disintegrants

Abstract

The purpose of the present study is to develop a novel liquid solid technique which enhances the dissolution rate of water insoluble or poorly water soluble drugs of Nilvadipine, which belong to class II of BCS. Generally the liquisolid technique is based upon the admixture of drug loaded with non volatile solutions (or) liquid drug incorporated with required carrier and coating materials in order to obtain a dry, non adherent, free flowing and compressible powder. Various non volatile solvents used were Propylene glycol, Poly ethylene glycol. The solubility of drug in the non volatile solvents plays an important role in this formulation Avicel PH 102 and aerosil were used as carrier and coating materials. Super disintegrants were used to increase the dissolution rate.Evaluation tests such as Disintegration time, Friability, Hardness and in-vitro dissolution studies were conducted. Amongst all the formulations F14 was considered to be the best in which Propylene glycol is used and the drug release was found to be 97% in 10 min.

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Published

01-07-2014

How to Cite

Hussain, M. A., M. Gorre, T. R. Rao, and M. Anjum. “PREPARATION AND EVALUATION OF NILVADIPNE LIQUISOLID COMPACTS”. International Journal of Pharmacy and Pharmaceutical Sciences, vol. 6, no. 7, July 2014, pp. 1-8, https://www.innovareacademics.in/journals/index.php/ijpps/article/view/2046.

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Review Article(s)