MULTIPARTICULATE DRUG DELIVERY SYSTEMS USING NATURAL POLYMERS AS RELEASE RETARDANT MATERIALS
Keywords:Multiparticulate drug delivery systems, Natural polymers, Drug release retardant materials, Gums, Mucilages, Polysaccharides
Now-a-days, the emphasis of pharmaceutical researchers is turned towards the development of more efficacious drug delivery systems with already existing molecule. However, in recent applications, Multiparticulate drug delivery systems (MDDS) are gaining much favor over single- unit dosage forms because of their potential benefits like predictable gastric emptying, least risk of dose dumping, flexible release pattern and increased bioavailability with minimum inter- and intra- subject variability. The advances in such drug delivery systems have simultaneously urged the discovery of novel excipients which are safe and fulfill specific functions and directly or indirectly influence the rate and extent of release and/or absorption. The plant derived gums and mucilages comply with many requirements of pharmaceutical excipients as they are non-toxic, stable, easily available, associated with less regulatory issues as compared to their synthetic counterpart and inexpensive; also these can be easily modified to meet the specific need. The pharmaceutical scientists have achieved a great success in developing most therapeutic systems with suitable natural polymer. The current article focuses on the merits, limitations, types of MDDS and application of natural polymer as drug release retardant material for MDDS with supportive studies on natural polymer and MDDS currently available in the market.
Kaur T, Bhawandeep G, Sandeep Kumar, Gupta GD. Mouth dissolving tablets: a novel approach to drug delivery. Int J Curr Pharm Res 2011;3(1):1-7.
Sirisha KVR, Vijayasri K, Devanna N, Kamalakar. Formulation and in vitro evaluation of Esomeprazole delayed release multi-particulate capsules. Int J Res Pharm Sci 2013;4(3):328-35.
Bipin Gandhi, Jagdish Baheti. Multiparticulates drug delivery systems: a review. Indian J Pharm Chem Sci 2013;2(3):1620-6.
NS Dey, S Majumdar, MEB Rao. Multiparticulate drug delivery systems for controlled release. Trop J Pharm Res 2008;7(3):1067-75.
Mahesh K Baramade, Shailesh L Patwekar. Controlled release approach to novel multiparticulate drug delivery systems. Int J Pharm Pharm Sci 2012;4(3):757-63.
Shaji Jessy, Shinde Amol B. Oral multiparticulate pulsatile drug delivery systems: a review. Int Res J Pharm 2011;2(2):22-7.
Navnit H Shah. Hoffmann La-Roche, Inc. Multi-Particulate Dosage Form for Oral Controlled Release: Development Considerations. Available from URL: http: //mediaserver.aaps.org/meetings/09am/slides/11.8.09_sun/410/0830/navnit_shah.pdf
Khyati Patel, Upendra Patel, Bhavin Bhimani, Ghansyam Patel, Dhiren Daslaniya. Extended release oral drug delivery system. Int J Pharm Res Bio-Sci 2012;1(3):1-26.
Vibhav Patel, Pranav Patel, Yogeshwar Thakkar, Praful Bharadia. Multiparticulate as a potential approach for colon targeted drug delivery system: a review. Int J Univer Pharm Life Sci 2012;2(3):131-46.
Joana mota. Matrix-and Reservoir-type Oral Multiparticulate Drug delivery systems.[Dissertation]. Berlin; 2010. p. 2-8.
Kamat Akshay Ramesh, Shabaraya AR, Azharuddin Mohd. Pulsatile drug delivery systems using natural polymers as release modifiers. Int Res J Pharm 2012;3(12):42-5.
Kumar Amit, Ranga Sonam. Pulsatile drug delivery system: method and technology review. Int J Drug Dev Res 2012;4(4):95-107.
Sirisha KVR, Vijayasri K, Suresh K, Kamalakar Reddy G. Multiple unit pellet systems: a review. Int J Pharm 2012;2(2):419-25.
Amelia M Avachat, Rakesh R Dash, Shilpa N Shrotriya. Recent investigations of plant based natural gums, mucilages and resins in novel drug delivery systems. Ind J Pharm Edu Res 2011;45(1):86-99.
Krushna kumar J Gandhi, Subhash V Deshmane, Kailash R Biyani. Polymers in pharmaceutical drug delivery system: a review. Int J Pharm Sci Rev Res 2012;14(2):57â€66.
Sandhya P, Siddiqua Habeeb, Sunitha M, Rao Patnaik KSK, Subrahmanyam CVS. A novel approach in modified release dosage forms. Formulation and evaluation of oral controlled release matrix tablets of etodolac. Asian J Pharm Res 2013;3(2):60-5.
Ramadevi K, Padmavathi K, Sravani N, Chandra Sekhara Rao G. Formulation and evaluation of diclofenac sodium sustained release tablets using seed powder of strychnos potatorum. Int J Biopharm 2013;4(2):110-4.
Nikhil Sachan K, Ghosh SK, Seema Pushkar. The Science of Polymeric plant based excipients in pharmaceutical drug delivery systems: Global perspective of Biological Researches, Seminar; 2010. p. 135-50.
Dharmendra S, Surendra JK, Sujata M, Shweta S. Natural excipients-a review. Int J Pharm Biol Arch 2012;3(5):1028-34.
Shanmugam S, Manavalan R, Venkappaya D, Sundaramoorthy, et al. Natural polymers and their applications. Natl Prod Radiance 2005;4(6):478-81.
Kumar S, Gupta SK. Natural polymers, gums and mucilages as excipients in drug delivery. Polim Med 2012;42(3-4):191â€“7.
Deveswaran R, Sravani B, Bharath S, Basavaraj BV, Madhavan V. Development of sustained release Metformin hydrochloride tablets using a Natural polysaccharide. Int J App Pharm 2012;4(2):23-9.
Amir Shaikh, Parvez Shaikh, Yogesh Pawar, Subhash Kumbhar, Ramesh Katedeshmukh. Effect of gums and excipients on drug release of ambroxol Hcl sustained release matrices. Int J Curr Pharm Res 2011;6(1):11-5.
Abu bakar, Ujjwal Nautiyal, Senthil Kumar M, Bharat Bhusan. Polymeric systems as controlled release drug products: a review. Int J Pharm Med Res 2014;2(2):72-7.
Gowda DV, Anjana John, Zeinul Hukuman. Preparation, Evaluation and Bioavailability studies of Propafenonr hydrochloride loaded with gum Microspheres for controlled study. Int J Pharm Bio Sci 2013;4(2):1036â€“49.
Razia Begum Sk, Mahidhar Reddy D, Jyothirmai K, Dileep Kumar GV, Jayasree S, JeevanKumar J, et al. A novel review on natural polymers used in formulation of pharmaceutical dosage forms. Int J Pharm Natl Med 2013;1(1):71-8.
Krishnarajan D, Mahesh Reddy C, Sasikanth Kanikanti, Senthil Kumar N, Purushothaman M. Formulation and evaluation of sustained release matrix tablets of levofloxacin using natural polymer. Pharmacophore 2013;4(5):146-57.
Kavitha Reddy, Krishna Mohan G, Shobharani Satla, Switi Gaikwad. Natural polysaccharides: versatile excipients for controlled drug delivery systems. Asian J Pharm Sci 2011;6(6):275-86.
Raju Onkar Sonawane, Deepali Gawale, Vishal Vijay Pandey, Pundikarao IGE. Formulation and In-vitro characterization of multiple unit sustained release matrix pellets of lornoxicam using natural gums. Indian J Novel Drug Delivery 2013;5(4):208-20.
Kamat Akshay Ramesh, et al. Formulation and evaluation of pulsatile drug delivery system containing indomethacin using natural polymers. Int Res J Pharm 2013;4(2):111-4.
Sarojini Sarangapani, Manavalan Rajappan. Lansoprazole release from a floating dosage form based on the natural polymer of delonix regia. Int J Pharm Tech Res 2012;4(3):1085-95.
Dharmarajsinh Chauhan, Axay Patel, Shrenik Shah. Influence of selected natural polymers on in-vitro release of colon targeted mebeverine HCL matrix tablet. Int J Drug Dev Res 2012;4(2):247-55.
Nagamani Bolla, Rajan Raju CH, Sarat Chandra K, GSN Koteswara Rao, Uma Devi P. Effect of natural polymers on controlled release of irbesartan from acacia and kernel loaded microspheres. Int J Inv Pharm Sci 2013;1(4):282-7.
Bipin Gandhi R, Bhatu Badgujar P, Ankit Kasliwal V. Development and in vitro evaluation of multiparticulate system using novel coating material for controlled drug delivery system. Int J Pharm Pharm Sci 2011;3(3):96-9.
Abdul Ahad, et al. Design and evaluation of sustained release matrix tablets of Glimepiride based on combination of natural and synthetic Polymers. Int J Appl Biol Pharm Technol 2010;1(3):770-7.
Vinaya OG, KG Revi kumar. Development of oral sustained release tablets of theophylline. Res J Pharm Biol Chem Sci 2012;3(4):494-506.
Basappa Veerabhadraiah Basavaraj, Naramsetty Saritha, Srinivasan Bharath, Rajamanickam Deveswaran, Varadharajan Madhavan. Vigna mungo mucilage-a natural polymer in the design of matrix based sr tablet of aceclofenac. Int J Pharm Sci Rev Res 2013;21(2):125-30.
Prakash Pawan, Kumar Nitin. Design and development of sustained release matrix tablet of diclofenac sodium using natural polymer. Int Res Pharm 2013;4(1):169-76.
Jani GK, Shah DP. Evaluation of mucilage of Hibiscus rosasinensis Linn as rate controlling matrix for sustained release of diclofenac. Drug Dev Ind Pharm 2008;34(8):807-16.
Inderbir Singh, Gurpreet Arora, Karan Malik, Sandeep Arora. Formulation and Evaluation of controlled release muchoadhesive matrix tablets: assessment of myrrh oleo gum resin as a natural pharmaceutical excipient. Int J Pharm Sci Drug Res 2011;3(2):84-8.
Kamble et al. Evaluation of drug release retardant potential of Ocimum tenuiflorumlinn. Seed mucilage isolated by Defatting method. Int J Pharm Chem Biol Sci 2012;3(1):68-74.