MULTIPARTICULATE DRUG DELIVERY SYSTEMS USING NATURAL POLYMERS AS RELEASE RETARDANT MATERIALS
Keywords:
Multiparticulate drug delivery systems, Natural polymers, Drug release retardant materials, Gums, Mucilages, PolysaccharidesAbstract
Now-a-days, the emphasis of pharmaceutical researchers is turned towards the development of more efficacious drug delivery systems with already existing molecule. However, in recent applications, Multiparticulate drug delivery systems (MDDS) are gaining much favor over single- unit dosage forms because of their potential benefits like predictable gastric emptying, least risk of dose dumping, flexible release pattern and increased bioavailability with minimum inter- and intra- subject variability. The advances in such drug delivery systems have simultaneously urged the discovery of novel excipients which are safe and fulfill specific functions and directly or indirectly influence the rate and extent of release and/or absorption. The plant derived gums and mucilages comply with many requirements of pharmaceutical excipients as they are non-toxic, stable, easily available, associated with less regulatory issues as compared to their synthetic counterpart and inexpensive; also these can be easily modified to meet the specific need. The pharmaceutical scientists have achieved a great success in developing most therapeutic systems with suitable natural polymer. The current article focuses on the merits, limitations, types of MDDS and application of natural polymer as drug release retardant material for MDDS with supportive studies on natural polymer and MDDS currently available in the market.
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