SPECTROPHOTOMETRIC METHODS FOR THE DETERMINATION OF TADALAFIL IN PHARMACEUTICAL FORMS

Authors

  • Safwan Fraihat Department of Chemistry, College of Science, Al-Jouf University Sakaka-Saudi Arabia.

Keywords:

Tadalafil, Spectrophotometric determination, Oxidation, Drug formulation

Abstract

Objective: To develop and validate simple and reproducible spectrophotometric methods for the determination of Tadalafil (TDF) in pure and pharmaceutical form.

Methods: Methods (A and B) were developed, method A is based on oxidation of (TDF) with a known excess amount of Ce(IV) then estimation of the unreacted amount of Methyl orange (MO) dye at 507 nm, Method B is based on the oxidation of (TDF) with excess N-bromosuccinamide then estimation the amount of Indigo carmine (IC) at 610 nm.

Results: The methods were linear in the concentration ranges 18–60 and 10–55 µg/ml with correlation coefficients of 0.993 and 0.992 and limits of detection LOD of 10.5 and 5.3 µg/ml for the two methods respectively. The proposed methods were applied for the determination of the drug in pharmaceutical formulations with recovery and relative standard deviations of 97% ± 1.4 and 98% ± 1.1 for the two methods.

Conclusion: the developed methods are equally accurate, precise and reproducible compared to the official methods.

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References

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Published

01-07-2014

How to Cite

Fraihat, S. “SPECTROPHOTOMETRIC METHODS FOR THE DETERMINATION OF TADALAFIL IN PHARMACEUTICAL FORMS”. International Journal of Pharmacy and Pharmaceutical Sciences, vol. 6, no. 7, July 2014, pp. 443-5, https://www.innovareacademics.in/journals/index.php/ijpps/article/view/2229.

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