• S. M. Mallikarjuna Department of Chemistry, Sahyadri Science College (Autonomous), Shimoga 577203, Karnataka, India
  • Basawaraj Padmashali Department of Chemistry, Sahyadri Science College (Autonomous), Shimoga 577203, Karnataka, India, Department of Studies and Research in Chemistry, School of Basic Sciences, Rani Channamma University, Belagavi 591156, Karnataka, India
  • C. Sandeep Department of Chemistry, Sahyadri Science College (Autonomous), Shimoga 577203, Karnataka, India


Piperazine, Aldehydes, Cyclopropane, Antituberculosis, Anticancer


Objective: Synthesis, anticancer and antituberculosis studies for 1-(4-Chlorophenyl) cyclopropyl] (piperazin-1-yl) methanone derivates 3a-j

Methods: A series of new [1-(4-Chlorophenyl) cyclopropyl] (piperazin-1-yl) methanone derivates were synthesized using reductive amination method in presence of sodium triacetoxyborohydride to yield piperzine derivatives 3a-j. The structures of all newly synthesized compounds have been characterised by elemental analysis and spectral studies.

Results: Five selected compounds have been screened for invitro anticancer activity against human breast cancer cell line MDA-MB-435 at 10, 20, 40 and 80 µG/mL concentration using sulforhodamine B assay method. and Two compounds 3a and 3c have shown in vitro anticancer activity.

Five selected compounds have been screened for anti-tuberculosis activity using Middlebrook 7H-9 broth and standard strain of M. tb h37Rv. Three compounds 3a, 3b and 3c have shown significant antituberculosis

Conclusion: Synthesis of [1-(4-Chlorophenyl) cyclopropyl] (piperazin-1-yl) methanone derivates 3a-j simple and convenient method. Some of the tested compounds have exhibited significant antituberculosis and anticancer activity. Compound 3c showed both antituberculosis and anticancer activity.


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How to Cite

Mallikarjuna, S. M., B. Padmashali, and C. Sandeep. “SYNTHESIS, ANTICANCER AND ANTITUBERCULOSIS STUDIES FOR [1-(4-CHLOROPHENYL) CYCLOPROPYL] (PIPERAZINE-YL) METHANONE DERIVATES”. International Journal of Pharmacy and Pharmaceutical Sciences, vol. 6, no. 7, July 2014, pp. 423-7,



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