• R. K. Sharma Reproductive Physiology Laboratory, Department of Zoology, Kurukshetra University, Kurukshetra 136119
  • A. K. Goyal Reproductive Physiology Laboratory, Department of Zoology, Kurukshetra University, Kurukshetra 136119


Testis, Germ Cells, Leydig Cells, Seminiferous Tubule, Pesticides, Endocrine Disruptors, Semen


The extensive use of pesticides in agricultural practices has resulted in contamination of food and food resources. A number of animal species including humans have accumulated traces of pesticides through food chain. These toxic chemicals influence the physiology of numerous non-target species including man. The effects of many pesticides have been analyzed using in vivo and in vitro techniques and degenerative changes induced by the toxic chemicals have been reported even at nanomolar concentrations. The adverse effects on the male reproductive system include direct damage of the cells or disruption of the developmental pathways directly or through endocrine modifications. Toxic pesticides are known to cause Germ cells disintegration, loss of Leydig cells, atresia in Sertoli cell, degeneration of seminiferous tubules, alternation in spermatogenesis, depletion in semen quality, teratospermia and endocrine disruption. For ensuring pesticide free food and food supplements it is recommended that biological alternative should be explored to safeguard good health of plants, animals and humans.


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How to Cite

Sharma, R. K., and A. K. Goyal. “AGRO-PESTICIDES AND ANDROLOGY”. International Journal of Pharmacy and Pharmaceutical Sciences, vol. 6, no. 10, Oct. 2014, pp. 12-19,



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