• Shrinath Shah Department of Pharmaceutics, Parul Institute of Pharmacy, Limda, Vadodara, Gujarat-391760 India
  • Sulekha Bhadra Department of Pharmaceutics, Parul Institute of Pharmacy, Limda, Vadodara, Gujarat-391760 India


Celecoxib, Transmucosal route, In-situ gel, Partial factorial study, Pharmacokinetic study


Objective: The main aim of the present study was development of mucoadhesive insitu gel for transmucosal delivery of celecoxib to increase its bioavailability by avoiding first pass metabolism. In the present study, transmucosal route was used for delivery of celecoxib so as to bypass the first pass metabolism seen in drug with oral route.

Methods: Temperature sensitive bio-adhesive in situ gel was prepared for the delivery of celecoxib in the rectal cavity. Optimization of the formulation was done using partial factorial (2[4-1]) design considering the concentration all the excipients as independent variables.

Results: The optimized formulation containing 0.71% polymer, 3.5% NaCl, 9.12% PEG 400, 0.5% sodium lauryl sulfate was found to possess gelling temp 38 C, bio adhesion strength 4.05 g/cm2 and 88.39%  in vitro drug release in three hours. Pharmacokinetic study of the optimized batch was performed in male Wistar rats. It was found that the bioavailability of in situ formulation was increased by 1.54 folds as compared to that of the marketed formulation by same route.

Conclusion: It was concluded that development of mucoadhesive insitu gel for transmucosal delivery of celecoxib was found to be a promising approach to obtain celecoxib drug with increased in the bioavailability of the drug.


Download data is not yet available.


Ceecoxib.Drug bank, Aug 28,2013.Available at:www.

United States Pharmacopeia. The official compendia of standards. 36th Revision; 31st Edn. 2013. p. 2897.

Tripathi KD. Essential of Medical Pharmacology. 5th edition. Jaypee Brother’s Medical Publisher’s Ltd; 2003. p. 8.

Tangri P. Oral Mucoadhesive drug delivery system. Int J Biopharm 2011;2(6):36-46.

Patel AR. Mucoadhesive drug delivery systems. Int J Pharm Life Sci 2011;2(6):848-56.

Khar A. Mucoadhesive drug delivery system. Drug Dev Ind Pharm 1997;23(5):489-515.

Sharma D, Tamar RS. In-situ gel system for ophthalmic preparation. Innov J Health Sci 2013;1(1):1-10.

Rathore KS. In situ gelling ophthalmic drug delivery system: An overview. Int J Pharm Sci 2010;2(4):30-4.

Mohan EC, Kandukuri JM, Allenki V. Preparation and Evaluation of In situ gels for ocular drug delivery. J Pharm Res 2009;2(6):1089-94.

Gratieri T, Samento EMR, Freitas OV, Lopez FV. A polaxmer/chitosan insitu forming gel with prolonged retention time for ocular delivery. Eur J Pharm Biopharm 2010;75(2):186-93.

Bromberg LE, Ron E. Temperature-responsive gels and thermo gelling polymer matrices for protein and peptide delivery. Int J Pharm 2011;4(1):217-50.

Rehman TU, Tavelin S. Chitosan in situ gelation for improved drug loading and retention in polaxamer 407 gel. Int J Pharm 2011;409:19–29.

Karade P, Shah RR, Chougule DD, Bhise SB. Formulation and evaluation of gel. J Drug Del Therap 2012;2(3):132-9.

Rathapon A, Thanasanchokpibull S. Optimization and evaluation of thermo responsive diclofenac sodium ophthalmic in situ gel. Int J Pharm 2011;411(2):128-35.

Bhatia HB, Sachan A, Bhandari A. Studies on thermo reversible mucoadhesive ophthalmic in situ gel of azithromyicin. J Drug Del Therap 2013;3(5):106-9.

Patil A, Tagalpallewar AA, Rasve GM, Bendre AV. A novel ophthalmic drug delivery system. Int J Pharm Sci Res 2012;3(9):2938-46.

Bankhele S, Harale RB, Rao MP, Dholka MV. Thermoreversible In-situ ophthalmic gelling system of levofloxacin formulation & optimization by factorial design. Asian J Pharm Sci 2012;2(3):100-6.

Gareth L. Experimental design, Published by Informa healthcare Pvt. Ltd. 19th edition; 2010. p. 147-58.

Brahmankar DM, Jaiswal S. Biopharmaceutics & Pharmacokinetics. 25ndEdn. Vallabh Prakashan 2011:5-75.

Jadhav KG, Gowekar NM, Gowekar SN. A Validated RP-HPLC Method for the determination of celecoxib in bulk and pharmaceutical dosage form. Int J Res Pharm Biomed Sci 2008;3(3):1313-6.

Shakeel F, Baboota S, Ahuja A, Ali J, Sheikh S. Skin permeation mechanism and bioavailability enhancement of celecoxib from transdermally applied nanoemulsion. J Nanobio 2008;6(8):1-11.

Sunil C Joshi. Sol-Gel behavior of hydroxypropyl methylcellulose (hpmc) in ionic media including drug release. Materials 2011;4:1861-905.

Haque A, Morris ER. Thermogelation of methylcellulose. part i: molecular structures and processes. Carbohydrate Polymer 1993;22:161-73.

Kundu PP, Kundu M. Effect of salts and surfactant and their doses on the gelation of extremely dilute solutions of methyl cellulose. Polymer 2001;42:2015-20.



How to Cite

Shah, S., and S. Bhadra. “MUCOADHESIVE IN-SITU GEL FOR TRANSMUCOSAL DELIVERY OF CELECOXIB”. International Journal of Pharmacy and Pharmaceutical Sciences, vol. 6, no. 10, Oct. 2014, pp. 221-7,



Original Article(s)