ANTI-INFLAMMATION EFFECTS OF BIOACTIVE FRACTION DLBS0533 CONTAINING PHALERIA MACROCARPA AND NIGELLA SATIVA ON ANIMAL MODEL
Keywords:DLBS0533, Anti-inflammation, Mice, Edema, Carragenan
Objective: Â DLBS0533 extract is a bioactive fraction obtained from combination of Phaleria macrocarpa and Nigella sativa. This present study aims to observe its potentially anti-inflammatory activities using carragenaan-induced paw edema in mice as animal model.
Methods: Â Mice were divided into control, positive control and dose groups. Diclofenac potassium was used as a positive control. Treatment DLBS0533 was given at dose 39, 78 and 156 mg/kg body weight (b. w.). Edema thickness was examined for 6 hours.
Results: Â Reduction in edema is shown in 27.26%; 30.71% and 32.72% at dose of 39, 78 and 156 mg/kg b. w., respectively. Comparation between dose groups and positive control group show that dose 156 mg/kg b. w. did not give significantly different. Therefore, dose 39 and 78 mg/kg b. w. also gave anti-inflammatory activities proved by reduction in edema.
Conclusions:Â Taken together, DLBS0533 potentially have anti-inflammatory activities.
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