• Nisakorn Saewan School of Cosmetic Science, Mae Fah Luang University, Muang, Chiang Rai 57100, Thailand
  • Anongnuch Thakam School of Cosmetic Science, Mae Fah Luang University, Muang, Chiang Rai 57100, Thailand
  • Ampa Jintaisong School of Cosmetic Science, Mae Fah Luang University, Muang, Chiang Rai 57100, Thailand
  • Krisada Kittigowitana School of Cosmetic Science, Mae Fah Luang University, Muang, Chiang Rai 57100, Thailand


Anti-tyrosinase, Curcumin metal complexes, Cytotoxicity


Objective: The objective of this study is investigating the potential of curcumin metal complexes in pharmaceutical and cosmetic products.

Methods: Curcumin was complexed with five divalent transition metals (Zn(II), Cu(II), Fe(II), Mn(II), and Mg(II)) and then investigated for their anti-tyrosinase activity and their mode of inhibition against mushroom tyrosinase and cytotoxicity against KB and MCF-7 cell lines.

Results: The tyrosinase inhibition of curcumin increased in the presence of Mn (II) and Zn (II); however, the activity was reduced after complexingwith Cu (II), Fe (II), and Mg (II). Curcumin manganese complex (curcumin-Mn) exhibited the highest potent anti-tyrosinase activity with classical noncompetitive inhibitor which showed the inhibition constant (KI)of 3.57 µg/mL(7.58µg/mL for free curcumin). For the cytotoxicity against KB and MCF7 cell lines, free curcumin showed cytotoxicity against both KB (IC50 9.58 mg/mL) and MCF7 (13.86 mg/mL) cancer cell lines;   whereas, it was found to be lower in the metal complexes.

Conclusion: This study suggests a potential use of the curcumin-Mn and Zn as a depigmentation agent in cosmetic products.


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How to Cite

Saewan, N., A. Thakam, A. Jintaisong, and K. Kittigowitana. “ANTI-TYROSINASE AND CYTOTOXICITY ACTIVITIES OF CURCUMIN-METAL COMPLEXES”. International Journal of Pharmacy and Pharmaceutical Sciences, vol. 6, no. 10, Oct. 2014, pp. 270-3,



Original Article(s)