ANTIMICROBIAL PROFILES, ANTIDIARRHEAL AND ANTIPYRETIC CAPACITIES OF PHENOL ACID RICH-FRACTIONS FROM XIMENIA AMERICA L., (OLACACEAE) IN WISTAR ALBINO RATS

Authors

  • Kiessoun Konate Laboratory of Food Biochemistry, Enzymology, Biotechnology and Bioinformatic, University of Ouagadougou, 03 P.O.Box: 848, Ouagadougou 03, Burkina Faso. University of Dedougou, Burkina Faso.Training and Research Unit in Applied and Technological Sciences, P.O. Box 176, Dedougou, Burkina Faso Laboratory of Animal Physiology,Electrophysiology and Pharmacology, Faculty of Sciences, University of Science and Technology of Masuku, Franceville, Gabon.
  • Meda Nag Tiero Roland Laboratory of Research and Teaching in Animal Health and Biotechnology, University Nazi Boni of Bobo Dioulasso, 01 P.O. Box 1091, Bobo Dioulasso 01, Burkina Faso
  • Diao Mamounata Laboratory of Food Biochemistry, Enzymology, Biotechnology and Bioinformatic, University of Ouagadougou, 03 P.O.Box: 848, Ouagadougou 03, Burkina Faso.
  • Kassi Yomalan Laboratory of Animal Physiology, UFR Bioscience, University of Felix Houphouet Boigny of Abidjan, 22 P.O. Box 582, Abidjan 22, Ivory Cost
  • Oksana Sytar Department of Plant Physiology and Ecology, Taras Shevchenko National University of Kyiv, Volodymyrs’ka Street 64, Kyiv 01601, Ukraine
  • Alain Souz Laboratory of Animal Physiology,Electrophysiology and Pharmacology, Faculty of Sciences, University of Science and Technology of Masuku, Franceville, Gabon.
  • Marian Brestic Department of Plant Physiology, Slovak Agriculture University in Nitra, A. Hlinku 2, 94976 Nitra, Slovakia
  • Mamoudou Hama Dicko Laboratory of Food Biochemistry, Enzymology, Biotechnology and Bioinformatic, University of Ouagadougou, 03 P.O.Box: 848, Ouagadougou 03, Burkina Faso.

DOI:

https://doi.org/10.22159/ijpps.2018v10i10.25485

Keywords:

Ximenia americana L, Phenol acid-rich fractions, Roots, Antimicrobial and antidiarrheal capacities

Abstract

Objective: The present study aim to evaluate antimicrobial and antidiarrheal activities of phenol acid-rich fractions of roots from Ximenia americana L., in animal models in order to confirm the ethnomedicinal use of Ximenia Americana L., roots.

Methods: In vitro antibacterial (Minimum inhibitory concentration (MIC), Minimum bactericidal concentration (MBC) and time-kill studies) of phenol-rich fractions of roots from Ximenia americana L., was assessed using eight bacteria strains (Gram-negative). The anti-diarrheal activity was evaluated using castor using castor oil induced diarrhea whereas Anti-secretory activity was investigated using castor oil-induced enteropooling assay examined in animal models respectively.

Results: All test bacteria were susceptible to the phenol-rich fractions. Time-kill results showed that after 5 h exposition there was no viable microorganism in the initial inoculum. Moreover, phenol acid-rich fractions of roots (100-200 and 300 mg/kg, p. o.) produced dose-dependent and significant (p<0.05-0.001) protection of rats against castor oil-induced diarrhea, and delayed gastric emptying. Phenol acid-rich fractions of roots, dose-dependently and significantly (p<0.05-0.001) delayed the onset of castor oil induced diarrhea, decreased the frequency of defecation, and reduced the severity of diarrhea in the rats. Phenol acid-rich fractions caused dose-related inhibition of castor-oil-induced enteropooling in rats.

Conclusion: The data analysis indicates that the tested of phenol-rich fractions has significant effects when compared with the standard antibiotic. These results, therefore, justify the traditional use of Ximenia americana L. About antidiarrheal activity, the findings of this study indicate that phenol acid-rich fraction possesses antidiarrheal property in rats. These findings confirm the ethnomedicinal use of Ximenia americana L., roots valuable natural remedy for the treatment, management and/or control of diarrhea.

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Published

01-10-2018

How to Cite

Konate, K., M. N. T. Roland, D. Mamounata, K. Yomalan, O. Sytar, A. Souz, M. Brestic, and M. H. Dicko. “ANTIMICROBIAL PROFILES, ANTIDIARRHEAL AND ANTIPYRETIC CAPACITIES OF PHENOL ACID RICH-FRACTIONS FROM XIMENIA AMERICA L., (OLACACEAE) IN WISTAR ALBINO RATS”. International Journal of Pharmacy and Pharmaceutical Sciences, vol. 10, no. 10, Oct. 2018, pp. 62-68, doi:10.22159/ijpps.2018v10i10.25485.

Issue

Vol 10, Issue 10, 2018

Section

Original Article(s)
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