ANTI-DIABETIC ACTIVITY OF HYDROALCOHOLIC EXTRACT OF EUGENIA JAMBOLANA LEAVES IN ALLOXAN INDUCED DIABETIC RATS
Keywords:Histopathological, Antidiabetic activity, Hydroalcohol and Eugenia jambolana leaves
Objective: The present study was carried out to evaluate the antidiabetic activity of hydroalcoholic extracts of Eugenia jambolana leaves.
Methods: The hydroalcoholic extracts of Eugenia jambolana by alloxan induced diabetic rats for 20 days. At high dose (400â€‰mg/kg) it is exhibited significant anti- hyperglycaemic activity than hydroalcoholic extracts of Eugenia jambolana at low dose (200â€‰mg/kg) in diabetic rats.
Results: The hydroalcoholic extracts of Eugenia jambolana also showed improvement in parameters like body weight, Serum Cholesterol level and hepatic glycogen as well as regeneration of beta-cells of pancreas in diabetic rats.
Conclusion: Histopathological studies reinforce the healing of kidney by hydroalcoholic extracts of Eugenia jambolana leaves as a possible mechanism of their antidiabetic activity. The present study provides a proof for the strong chemo taxonomical relationship for the plant
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