ANTI-DIABETIC ACTIVITY OF HYDROALCOHOLIC EXTRACT OF EUGENIA JAMBOLANA LEAVES IN ALLOXAN INDUCED DIABETIC RATS

Authors

  • M. SHANKAR Department of Pharmaceutical Chemistry, Seven Hills College of Pharmacy, Tirupati - 517561, Andhra Pradesh, India
  • R. Suthakaran Department of Pharmaceutical Chemistry and Regulatory Affairs, Teegala Ramreddy College of Pharmacy, Meerpet, Hyderabad - 500097, Andhra Pradesh, India

Keywords:

Histopathological, Antidiabetic activity, Hydroalcohol and Eugenia jambolana leaves

Abstract

Objective: The present study was carried out to evaluate the antidiabetic activity of hydroalcoholic extracts of Eugenia jambolana leaves.

Methods: The hydroalcoholic extracts of Eugenia jambolana by alloxan induced diabetic rats for 20 days. At high dose (400 mg/kg) it is exhibited significant anti- hyperglycaemic activity than hydroalcoholic extracts of Eugenia jambolana at low dose (200 mg/kg) in diabetic rats.

Results: The hydroalcoholic extracts of Eugenia jambolana also showed improvement in parameters like body weight, Serum Cholesterol level and hepatic glycogen as well as regeneration of beta-cells of pancreas in diabetic rats.

Conclusion: Histopathological studies reinforce the healing of kidney by hydroalcoholic extracts of Eugenia jambolana leaves as a possible mechanism of their antidiabetic activity. The present study provides a proof for the strong chemo taxonomical relationship for the plant

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Author Biography

M. SHANKAR, Department of Pharmaceutical Chemistry, Seven Hills College of Pharmacy, Tirupati - 517561, Andhra Pradesh, India

PHARMACEUTICAL CHEMISTRY

References

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Published

01-10-2014

How to Cite

SHANKAR, M., and R. Suthakaran. “ANTI-DIABETIC ACTIVITY OF HYDROALCOHOLIC EXTRACT OF EUGENIA JAMBOLANA LEAVES IN ALLOXAN INDUCED DIABETIC RATS”. International Journal of Pharmacy and Pharmaceutical Sciences, vol. 6, no. 10, Oct. 2014, pp. 138-40, https://www.innovareacademics.in/journals/index.php/ijpps/article/view/2580.

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