• CHINNASAMY RAJARAM PRAKASH Department of Medicinal Chemistry, DCRM Pharmacy College, Jawaharlal Nehru Technological University, Hyderabad, Andhra Pradesh, India
  • Sundararajan Raja Department of Pharmaceutical Chemistry, GITAM Institute of Pharmacy, GITAM University, Visakhapatnam, Andhra Pradesh, India
  • Govidaraj Saravanan Medicinal Chemistry Research Laboratory, Bapatla College of Pharmacy, Bapatla 522101, Andhra Pradesh, India


Schiff bases, Mannich bases, Isatin, Anti-microbial activity


Objective: Synthesis and analgesic, anti-inflammatory and antimicrobial evaluation of some novel Schiff and Mannich bases of isatin derivatives.

Methods: A series of novel 3-(4-(2-(substituted benzylideneamino)thiazol-4-yl)phenylimino)-1-((dimethylamino)methyl)-5-fluoroindolin-2-one Schiff and Mannich base derivatives were synthesized by using various aromatic aldehydes with isatin derivatives. The chemical structures of all synthesized compounds were confirmed by IR, 1H-NMR, Mass spectra and elemental analysis. All the synthesized compounds were screened for its analgesic, anti-inflammatory and antimicrobial activity.

Results: The results of analgesic, anti-inflammatory and antimicrobial activity showed that some of the synthesized compounds were exhibited promising results.

Conclusion: This investigation identified the potent analgesic, anti-inflammatory and anti-microbial agents and these molecules will be subjected to further studies in our laboratory.


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How to Cite

PRAKASH, C. R., S. Raja, and G. Saravanan. “SYNTHESIS, ANALGESIC, ANTI-INFLAMMATORY AND IN VITRO ANTIMICROBIAL STUDIES OF SOME NOVEL SCHIFF AND MANNICH BASE OF 5-SUBSTITUTED ISATIN DERIVATIVES”. International Journal of Pharmacy and Pharmaceutical Sciences, vol. 6, no. 10, Oct. 2014, pp. 160-6,



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