A COMPARATIVE STUDY ON THE IN-VITRO ANTIMICROBIAL ACTIVITY OF THE ROOTS OF FOUR THOTTEA SPECIES
Keywords:Antimicrobial activity, Thottea species, MIC, Methanol extract
Objective: The main objective of the present study was to investigate the antimicrobial activity of the methanol extract of the roots of four Thottea species.
Methods: The root extracts of four Thottea species were subjected to antimicrobial assay by Minimum Inhibitory Concentration (MIC) and Agar Disc diffusion Assay against various medically important pathogens.
Results: It is evident from the study that. Significant antibacterial activity was recorded by Thottea sivarajanii and highest activity was recorded against Pseudomonas aeruginosa and Staphylococcus epidermis (64 Âµg/ml). Out of the four extracts tested for antifungal activity, Thottea barberi and Thottea ponmudiana recorded significant antifungal activity and the highest activity was recorded by T. barberi against Trichophyton rubrumÂ (16Âµg/ml).
Conclusion: Results offer a scientific basis for the traditional use of Thottea species in the treatment of microbial infections, showing that the plant extract has an enormous potential as a prospective alternative drug against microbial pathogens. The present study lays the basis for future studies, to validate the possible use of Thottea species as a candidate in the treatment of microbial infections.
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