ANTIBIOTIC SENSITIVITY PATTERN OF CITROBACTER SPP. ISOLATED FROM PATIENTS WITH URINARY TRACT INFECTIONS IN TERTIARY CARE HOSPITAL IN SOUTH INDIA

Authors

  • Metri Basavaraj C Shri B M Patil Medical College,
  • P Jyothi Shri B M Patil Medical College Bijapur

Keywords:

Anti-microbial resistance, Antibiotics, Citrobacter, Drug resistance, Urinary tract infections

Abstract

Objectives: Urinary tract infection (UTIs) caused by Citrobacter species have been described in 5 to 12% of bacterial urine isolates in adults. The genus Citrobacter is a distinct group of aerobic Gram-negative bacilli from the Enterobacteriaceae family. We report here the emergence of Citrobacter as an increasingly common urinary pathogen in patients attending this medical college.

Methods: The study was carried out over a period of 2 years from January 2010 to December 2011. Urine specimens from both outpatients and inpatients of our hospital were processed. Urine samples which yielded the growth Citrobacter spp. were included in the study

Results: E. coli was the most common organism isolated followed by Klebsiella spp. and Citrobacter spp. The most active antimicrobial agent against Citrobacter isolates was piperacillin-tazobactum (55% sensitive), closely followed by amikacin (47%).

Conclusion: The emergence of this usually rare organism as the third most common urinary pathogen, which is resistant to commonly available antibiotics is alarming. Such studies will guide clinicians to choose accurate empirical treatment options and will help to reduce the mortality and morbidity rates from infections.

 

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Author Biography

Metri Basavaraj C, Shri B M Patil Medical College,

  1. DR METRI  BASAVARAJ C *  M.D.

     Associate professor

     Department of Microbiology

                       BLDEU’s Shri B M Patil Medical college

                       Bijapur –Karnataka-586103                       

References

Cox CE. Nosocomial urinary tract infections. Urol 1988;32:210-5.

Steadman R, Topley N. The virulence of Escherichia coli in urinary tract. In: Brumfitt W, Jeremy MT, Hamilton Miller, editors. Urinary tract infections. 1st ed. London: Chapman and Hall; 1998. p. 37-41.

Metri BC, Jyothi P, Peerapur BV. Antibiotic resistance in Citrobacter spp. isolated from urinary tract infection. Urol Ann 2013;5:312-3.

Gill MA, Schutze GE. Citrobacter urinary tract infection in children. Pediatr Infect Dis J 1999;18:889-92.

Abbott S. Klebsiella, Enterobacter, Citrobacter and Serratia. In: Murray PR, Baron EJ, Pfaller MA, Tenover FC, Yolken RH,editors. Manual of clinical microbiology. 7 th ed. New York: ASM Press; 1999. p. 475-82.

Lavigne JP, Defez C, Bouziges N, Mahamat A, Sotto A. Clinical and molecular epidemiology of multidrug-resistant Citrobacter spp. infections in a French university hospital. Eur J Clin Microbiol Infect Dis 2007;26:439-41.

Crichton PB. Enterobacteriaceae: Escherichia, Klebsiella, Proteus and other genera. In: Collee JG, Fraser AG, Marmion BP, Simmons A, editors. Mackie and McCartney. Practical medical microbiology. 14 th ed. London: Churchill Livingstone; 1996. p. 361-84.

Murray PR, Holmes B, Aucken HM. Citrobacter, Enterobacter, Klebsiella, Plesiomonas, Serratia, and other members of the Enterobacteriaceae. In: Borriello SP, Murray PR, Funke G, editors. Topley and Wilson's microbiology and microbial infections. 10 th ed. London: Hodder Arnold; 2005. p. 1474-506

Metri BC, Jyothi P, Peerapur BV. Anti-microbial resistance profile of Citrobacter species in a tertiary care hospital of southern India. Indian J Med Sci 2011;65:429-35.

Collee JG, Duguid JP, Fraser AG, Marmion BP, Simmons A. Laboratory strategy in diagnosis of infective syndromes. In: Collee JG, Duguid JP, Fraser AG, Marmion BP, Simmons A (editors). Mackie and McCartney Practical Medical Microbiology, 14th ed. London: Churchill Livingstone; 1996. p. 53-94.

Cruickshank R, Duguid JP, Marmion BP. Tests for identification of bacteria. In: Medical Microbiology. 12th ed. London: Churchill Livingstone; 1975. p. 170-89.

Clinical and Laboratory Standards Institute. Performance standards for antimicrobial susceptibility testing; 16th informational supplement. M100-S16. Clinical and Laboratory Standards Institute, Wayne, PA; 2006.

Kurtoğlu MG, Opus A, Özdemir M, Baysal B. Isolation of citrobacters in various infections and their antimicrobial sensitivity rates. Kafkas Univ Vet Fak Derg 2011:17 (Suppl A):S99-S104.

Thapa B, Adhikari P, Mahat K, Chhetri MR, Joshi LN. Multidrug-resistant nosocomial Citrobacter in a hospital in Kathmandu. Nepal Med Coll J 2009;11:195-9.

Shih CC, Chen YC, Chang SC, Luh KT, Hsieh WC. Bacteremia due to Citrobacter species: significance of primary intraabdominal infection. Clin Infect Dis 1996;23:543-9.

Gales AC, Jones RN, Gordon A, Sader HS, Wilke WW, Beach ML, et al. Activity and spectrum of 22 antimicrobial agents tested against urinary tract infection pathogens in hospitalized patients in Latin America: Report from the second year of the SENTRY Antimicrobial Surveillance Program (1998). J Antimicrob Chemother 2000;45:295-303.

Drelichman V, Band JD. Bacteremias due to Citrobacter diversus and Citrobacter freundii: incidence, risk factors, and clinical outcome. Arch Intern Med 1985;145:1808-10.

Published

01-01-2015

How to Cite

C, M. B., and P. Jyothi. “ANTIBIOTIC SENSITIVITY PATTERN OF CITROBACTER SPP. ISOLATED FROM PATIENTS WITH URINARY TRACT INFECTIONS IN TERTIARY CARE HOSPITAL IN SOUTH INDIA”. International Journal of Pharmacy and Pharmaceutical Sciences, vol. 7, no. 1, Jan. 2015, pp. 252-4, https://www.innovareacademics.in/journals/index.php/ijpps/article/view/2753.

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