EVALUATION OF IN VITRO ANTICANCER POTENTIAL OF ETHANOLIC EXTRACT AND ITS DIFFERENT FRACTIONS OF CAESALPINIA BONDUC (L) ROXB SEEDS

Authors

  • Deepika K. S. N. Department of Biotechnology, School of Chemical and Biotechnology, SASTRA University, Thirumalaisamudram, Thanjavur 613401
  • Rama Navya K. Department of Biotechnology, School of Chemical and Biotechnology, SASTRA University, Thirumalaisamudram, Thanjavur 613401
  • Meenakshi Sundaram Muthuraman Department of Biotechnology, School of Chemical and Biotechnology, SASTRA University, Thirumalaisamudram, Thanjavur 613401
  • Ravichandran Natesan CARISM, SASTRA University, Thirumalaisamudram, Thanjavur 613401
  • David Raj C. CARISM, SASTRA University, Thirumalaisamudram, Thanjavur 613401
  • Brindha Pemaiah CARISM, SASTRA University, Thirumalaisamudram, Thanjavur 613401

Keywords:

Caesalpinia bonduc, Anticancer, In vitro, In silico

Abstract

Objective: The present study aims to evaluate the anticancer potential of ethanolic extract and its different fractions of Caesalpinia bonduc seeds against Ehrlich Ascites Carcinoma (EAC) cell lines.

Methods: Ethanolic extract and its fractions were subjected to preliminary phytochemical screening and anticancer activity by using in vitro anticancer assay. Chemical constituents of petroleum ether fraction of C. bonduc seeds were identified by using GC-MS and the active compounds were subjected to in silico studies.

Results: In vitro anticancer assay showed that the petroleum ether fraction of ethanolic extract of Caesalpinia bonduc seeds has potential anticancer activity.

Conclusions: Petroleum ether fraction of ethanolic extract of Caesalpinia bonduc seeds has significant anticancer activity. Further in-depth studies, could result in the development of a good anticancer agent from the seeds of Caesalpinia bonduc.

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References

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Published

31-08-2014

How to Cite

K. S. N., D., R. N. K., M. S. Muthuraman, R. Natesan, D. R. C., and B. Pemaiah. “EVALUATION OF IN VITRO ANTICANCER POTENTIAL OF ETHANOLIC EXTRACT AND ITS DIFFERENT FRACTIONS OF CAESALPINIA BONDUC (L) ROXB SEEDS”. International Journal of Pharmacy and Pharmaceutical Sciences, vol. 6, no. 8, Aug. 2014, pp. 311-4, https://www.innovareacademics.in/journals/index.php/ijpps/article/view/2785.

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Original Article(s)