CYTOTOXICITY OF BYRSONIMA DUCKEANA W. R. ANDERSON (MALPIGHIACEAE) ON COLON CANCER CELLS

Authors

  • Maria Christina Dos Santos Verdam Programade Pos Graduacao em Ciencias Farmaceuticas, Universidade Federal do Parana, Avenida Prefeito Lothario Meissner, 632, Jardim Botanico, 80210-170, Curitiba, Parana, Brazil 55413360-4070
  • Fernanda Guilhon-simplicio Faculdade de Ciencias Farmaceuticas, Universidade Federal do Amazonas, Rua Alexandre Amorim, 330, Aparecida, 69010-300, Manaus, Amazonas, Brazil 55 92 3305-1181
  • Cristiane Da Silva Paula Programade Pos Graduacao em Ciencias Farmaceuticas, Universidade Federal do Parana, Avenida Prefeito Lothario Meissner, 632, Jardim Botanico, 80210-170, Curitiba, Parana, Brazil 55413360-4070
  • Vinicius Bednarczuk De Oliveira Programade Pos Graduacao em Ciencias Farmaceuticas, Universidade Federal do Parana, Avenida Prefeito Lothario Meissner, 632, Jardim Botanico, 80210-170, Curitiba, Parana, Brazil 55413360-4070
  • Marilis Dallarmi Miguel Programade Pos Graduacao em Ciencias Farmaceuticas, Universidade Federal do Parana, Avenida Prefeito Lothario Meissner, 632, Jardim Botanico, 80210-170, Curitiba, Parana, Brazil 55413360-4070
  • Patricia Maria Stuelp Campelo Escolade Saude e Biociencia, Pontifícia Universidade Catolica do Parana, Rua Imaculada Conceicao, 1155, Prado Velho, 80215901, Curitiba, Parana, Brazil. 55 41 3221-7560
  • Obdulio Gomes Miguel Programade Pos Graduacao em Ciencias Farmaceuticas, Universidade Federal do Parana, Avenida Prefeito Lothario Meissner, 632, Jardim Botanico, 80210-170, Curitiba, Parana, Brazil 55413360-4070

Keywords:

Medicinal Plant, Alternative Medicine, Cytotoxicity, Cancer Cells

Abstract

Objective: The objective of this study was the cytotoxicity evaluation of the leaves extract and fractions of Byrsonima duckeana W. R. Anderson.

Methods: The toxicity on Artemia salina, haemolytic potential and cytotoxicity activities against two different cell lines a U937 cell line human, and HT29 tumor colon cell line of the leaves extract and fractions of Byrsonima duckeana W. R. Anderson were evaluated.

Results: There was no IC50 the Artemia salina assay. The chloroform and ethyl acetate fractions showed haemolytic activity. The results were satisfactory at the most polar fractions, with citotoxicity to the HT29 cell line.

Conclusion: The study provides preliminary evidence of cytotoxicity of the most polar fractions at the HT29 cell line, which can indicate a potencial source to offer substances with cytotoxic activity.

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References

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Published

01-11-2014

How to Cite

Santos Verdam, M. C. D., F. Guilhon-simplicio, C. D. S. Paula, V. B. De Oliveira, M. D. Miguel, P. M. S. Campelo, and O. G. Miguel. “CYTOTOXICITY OF BYRSONIMA DUCKEANA W. R. ANDERSON (MALPIGHIACEAE) ON COLON CANCER CELLS”. International Journal of Pharmacy and Pharmaceutical Sciences, vol. 6, no. 11, Nov. 2014, pp. 509-10, https://journals.innovareacademics.in/index.php/ijpps/article/view/2837.

Issue

Vol 6, Issue 11, 2014

Section

Short Communication(s)

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