UTILITY OF CERTAIN Ïƒ AND Ï€-ACCEPTORS FOR THE SPECTROPHOTOMETRIC DETERMINATION OF VORICONAZOL ANTIFUGAL DRUG IN PHARMACEUTICAL FORMULATION
Keywords:Voriconazole, Charge-transfer complexes, Spectrophotometry, Pharmaceutical formulations
Objective: Studies were carried out, for the first time, to investigate the charge-transfer reactions of voriconazole antifungal drug (VOR) as n-electron donor with the Ïƒ-acceptor iodine (I2) and various Ï€-acceptors: 7,7,8,8-tetracyanoquinodimethane (TCNQ); 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) and p-chloranilic acid (p-CLA).
Methods: The formation of the colored charge-transfer complexes were utilized in the development of simple, rapid and accurate spectrophotometric methods for the analysis of voriconazole in pure form as well as in its pharmaceutical formulation (tablets). Different variables affecting the reactions were studied and optimized.
Results: Under the optimum reaction conditions, linear relationships with good correlation coefficients (0.9994â€“0.9999) were found between the absorbance and the concentration of voriconazole in the range of 2.0â€“120 Î¼g mLâˆ’1. For more accurate analysis, Ringbom optimum concentration range was found to be between 4.0-110 Î¼g mL-1. The limits of detection ranged from 0.36 to 1.23Â Î¼gÂ mLâˆ’1andthe limits of quantification ranged from 1.20 to 4.10Â Î¼gÂ mLâˆ’1. A Job's plot of the absorbance versus the molar ratio of voriconazole to each of acceptors under consideration indicated (1:1) ratio.
Conclusion: The proposed methods were applied successfully for simultaneous determination of voriconazole in tablets with good accuracy and precision and without interferences from common additives. The results were compared favourably with the reported method.
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