OLEOGELS OF OLIVE OIL AND SOYBEAN OIL FOR TOPICAL DRUG DELIVERY: A COMPARATIVE ANALYSIS

DIPANJANA ASH; SUTAPA BISWAS MAJEE; GOPA ROY BISWAS

doi:10.22159/ijpps.2019v11i8.34040

Authors

DIPANJANA ASH Department of Pharmacy, NSHM Knowledge Campus, Kolkata-Group of Institutions, 124 B L Saha Road, Kolkata 700053
SUTAPA BISWAS MAJEE Department of Pharmacy, NSHM Knowledge Campus, Kolkata-Group of Institutions, 124 B L Saha Road, Kolkata 700053
GOPA ROY BISWAS Department of Pharmacy, NSHM Knowledge Campus, Kolkata-Group of Institutions, 124 B L Saha Road, Kolkata 700053

DOI:

https://doi.org/10.22159/ijpps.2019v11i8.34040

Keywords:

Accelerated thermal stability, Cogelator, Critical gelator concentration, Gel-matrix, Gel-sol transition temperature, Melt flow index, Span 40, Tween 80

Abstract

Objective: The objective of the present investigation was to develop olive and soybean oil-based oleogels with Span 40 and/or Tween 80 (as gelator and/or surfactant) and determine the critical gelator concentration (CGC), characterise and compare the rheological, thermal properties and drug release profile of the gels formed for topical delivery.

Methods: Olive and soybean oil-based Span 40 and Span 40/Tween 80 oleogel formulations were prepared by solid fiber mechanism and subjected to organoleptic evaluation, FT-IR spectroscopy, thermal analysis, rheological study, kinetic modeling of gelation and drug release.

Results: The critical gelator (Span 40) concentration was found to be lower for olive oil (12% w/v) and depend on the type of oil. Tween 80 reduced CGC of soybean oleogels only. Soybean oil-based oleogel containing 18% w/v Span 40 was found to form more flexible, less viscous and thermally less stable formulation with better release of paracetamol as evident from lower melt flow index, T_g value, lower β and higher α value compared to olive oil-based oleogel with 12% w/v Span 40 (CGC). Surfactant addition can be assumed to modify the microarchitecture of the oleogels to a great extent to produce more flexible and thermally stable gels with even better drug release profile. Span-Tween based soybean oleogel formed a gel-matrix whereas matrix in olive oil-based oleogels containing Span only became slightly flexible to release the drug in zero-order fashion on the addition of surfactant cogelator.

Conclusion: Nature of oil exerts profound influence on the rheological, thermal and release profile of oleogels containing Span 40 as gelator and/or Tween 80 as surfactant cogelator.

Downloads

Download data is not yet available.

References

Nigar KM, Sangramsinh LG, Veerendra CY. Organogel: factors and its importance. Int J Bio Chem Sci 2014;4:758-73.

Rehman K, Zulfakar MH. Recent advances in gel technologies for topical and transdermal drug delivery. Drug Dev Indian Pharm 2014;40:433–40.

Singh VK, Pramanik K, Ray SS, Pal K. Development and characterization of sorbitan monostearate and sesame oil-based organogels for topical delivery of antimicrobials. AAPS PharmSciTech 2015;16:293-305.

Shah DK, Sagiri SS, Behera B, Pal K, Pramanik K. Development of olive oil-based organogels using sorbitan monopalmitate and sorbitan monostearate: a comparative study. J Appl Poly Sci 2013;129:793-804.

Satapathy D, Sagiri SS, Pal K, Pramanik K. Development of mustard oil-and groundnut oil-based Span 40 organogels as matrices for controlled drug delivery. Des Monomers Polym 2014;17:545–56.

Iradhati AH, Jufri M. Formulation and physical stability test of griseofulvin microemulsion gel. Int J Appl Pharm 2017;9:23-6.

Daood NM, Jassim ZE, Gareeb MM, Zeki H. Studying the effect of different gelling agent on the preparation and characterization of metronidazole as topical emulgel. Asian J Pharm Clin Res 2019;12:571-7.

Almajidi YQ, Albaderi AA, Fadhel H. Enhance solubility and prolong release of prochlorperazine maleate using floating nanoemulsion in situ gel. Asian J Pharm Clin Res 2019;12:1-5.

Gupta R, Kumar M, Sharma HK. Span 80-tween 80 based fluid-filled organogel for topical delivery of fluconazole. Int J Sci Res Rev 2014;3:29-46.

Lin TK, Zhong L, Santiago JL. Anti-inflammatory and skin barrier repair effects of topical application of some plant oils. Int J Mol Sci 2018;19:1-21.

Balata GF, Moneom Shamardl H-El. Formulation of chlorpheniramine maleate in span 60/Tween20 based organogels for transdermal delivery. J Innov Pharma Bio Sci 2017;4:49-57.

Indian Pharmacopoeia; Government of India, Ministry of Health and Family Welfare Department. 7th edition; 2014. p. 1, 559-621.

Shukla AK, Yadav SK, Tiwari V. Linear models for S-shaped growth curves. J Stat Appl Prob 2015;4:113-7.

Friction welding of dissimilar plastic-based material by metal powder reinforcement. Singh R, Kumar R. Reference module in materials science and materials engineering. Hashmi MSJ. Editor. Dublin, Ireland; 2017. p. 1-16.

Bartosova L, Bajgar J. Transdermal drug delivery in vitro using diffusion cells. Curr Med Chem 2012;19:4671-7.

Organogels in controlled drug delivery. Singh VK, Behera B, Sagiri SS, Pal K, Anis A, Bhattacharya MK. Handbook of encapsulation and controlled release: Mishra M. Editor. London, UK: CRC Press; 2015. p. 1035-66.

Dautel OJ, Robitzer M, Lere Porte JP, Serein Spirau F, Moreau JJ. Self-organized ureido substituted diacetylenic organogel. Photopolymerization of one-dimensional supramolecular assemblies to give conjugated nanoﬁbers. J Am Chem Soc 2006;128:16213–23.

Li Y, Wang T, Liu M. Ultrasound induced formation of organogel from a glutamic dendron. Tetrahedron 2007;63:7468–73.

Murdan S, Gregoriadis G, Florence AT. Interaction of a nonionic surfactant-based organogel with aqueous media. Int J Pharm 1999;180:211–4.