A PILOT STUDY ON IDENTIFICATION AND MANAGEMENT OF DRUG INDUCED SEXUAL DYSFUNCTION: A COLLABORATIVE APPROACH BY CLINICAL PHARMACIST AND PSYCHIATRIST

IDENTIFICATION AND MANAGEMENT OF DRUG INDUCED SEXUAL DYSFUNCTION

Authors

  • BILESH SHAKYA Department of Pharmacy Practice, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Mysuru, Karnataka 570015, India
  • TIRIN BABU Department of Pharmacy Practice, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Mysuru, Karnataka 570015, India
  • MOHAMED SHAFI P. Department of Pharmacy Practice, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Mysuru, Karnataka 570015, India
  • VEMURI TEJASRI Department of Pharmacy Practice, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Mysuru, Karnataka 570015, India
  • JUNY SEBASTIAN Department of Pharmacy Practice, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Mysuru, Karnataka 570015, India
  • SHIVANANDA MANOHAR J. Department of Psychiatry, JSS Medical College and Hospital, JSS Academy of Higher Education and Research, Mysuru 570015, Karnataka, India
  • JISHA MYALIL LUCCA Department of Pharmacy Practice, Imam Abdulrahman Bin Faisal University, Dammam, Kingdom of Saudi Arabia

DOI:

https://doi.org/10.22159/ijpps.2020v12i2.34334

Keywords:

Sexual dysfunction, Drug-induced sexual dysfunction, Prevalence, Nil, Sex clinic

Abstract

Objective: To assess the role of clinical pharmacists in the identification and management of drug-induced sexual dysfunction in collaboration with the psychiatrist and also to determine the prevalence and pattern of drug-induced sexual dysfunction, identify nature and extend of drug-induced sexual dysfunction, and assess the pattern of management of drug-induced sexual dysfunction.

Methods: This periodic prevalence interventional study was carried out among patients who visited the psychiatric department of a university hospital over three month’s period. Patients were screened for sexual dysfunction using the Arizona Sexual Experience Scale (ASEX) by study pharmacists.

Results: Of the 100 patients reviewed, only 50% of subjects met the study criteria. Depression (42%) was the most common clinical diagnosis among the study patients. The overall prevalence of drug-induced sexual dysfunction was 16%. A higher incidence of drug-induced sexual dysfunction was observed in men (62.5%). Decrease libido (40%) was the most prominently observed drug-induced sexual dysfunction in both genders. Antidepressant (50%) was the most common class of drugs implicated in sexual dysfunction. Drug-induced sexual dysfunction was pharmacologically managed with vaginal lubrication (40%), Tadalafil (20%) and Tadalafil+Dapoxetine combination (40%).

Conclusion: With this study, provided a vision, further how prospective studies in this arena may be carried out for better understanding drug-induced sexual dysfunction and how a clinical pharmacist can contribute for better health care of patients in the sex clinic by collaborating with medical practitioners.

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References

Chunder R. Sexual dysfunction: an approach for the pharmacist. SA Pharm J 2011;78:18-21.

Mkele G. A review of medicines that affect sexual performance. SA Pharm J 2014;81:34-7.

Laumann EO, Paik A, Rosen RC. Sexual dysfunction in the United States: prevalence and predictors. JAMA 1999;281:537-44.

Lucca JM, Ramesh M, Ram D, Kurian J, Mathew N. Psychotropic medication-induced sexual dysfunction and its interference with patient's daily performance: a cross-sectional study. Egyptian J Psychiatry 2016;37:36.

Conaglen HM, Conaglen JV. Drug-induced sexual dysfunction in men and women. Aust Prescr 2013;36:42.

Boora K, Chiappone K, Dubovsky SL. Oxcarbazepine-induced reversible anorgasmia and ejaculatory failure: a case report. Prim Care Companion J Clin Psychiatry 2009;11:173-4.

Calabro RS, Ferlazzo E, Italiano D, Bramanti P. Dose-dependent oxcarbazepine-related anorgasmia. Epilepsy Behav 2010; 17:287-8.

Calabro RS, Italiano D, Pollicino P, Bramanti P. Oxcarbazepine-related retrograde ejaculation. Epilepsy Behav 2012;25:174-5.

Martin Morales A, Ibanez J, Machuca M, Pol Yanguas E, Schnetzler G, Renedo VP. The EPIFARM study: an observational study in 574 community pharmacies in Spain characterizing patient profiles of men asking for erectile dysfunction medication. J Sex Med 2010;7:3153-60.

Mohandas E. Roadmap to Indian psychiatry. Indian J Psychiatry 2009;51:173.

Goldstein I, Krane RJ. Drug-induced sexual dysfunction. World J Urol 1983;1:239-43.

Gregorian Jr RS, Golden KA, Bahce A, Goodman C, Kwong WJ, Khan ZM. Antidepressant-induced sexual dysfunction. Ann Pharmacother 2002;36:1577-89.

Lucca JM, Kurian J, Ramesh M, Ram D. Appraisal of clinical pharmacy services in the mental health unit of a South Indian tertiary care hospital. World J Pharm Pharm Sci 2014;3:780-91.

Clayton AH, Pradko JF, Croft HA, Montano CB, Leadbetter RA, Bolden Watson C, et al. Prevalence of sexual dysfunction among newer antidepressants. J Clin Psychiatry 2002;63:357-66.

Serretti A, Chiesa A. Antidepressivi e disfunzione sessuale: epidemiologia, meccanismi e strategie di trattamento. Giornale Italiano Psicopatologia 2010;16:104-13.

La Torre A, Giupponi G, Duffy DM, Pompili M, Grozinger M, Kapfhammer HP, et al. Sexual dysfunction related to psychotropic drugs: a critical review–part I: antidepressants. Pharmacopsychiatry 2013;46:191-9.

Baggaley M. Sexual dysfunction in schizophrenia: focus on recent evidence. Human psychopharmacology. Hum Psychopharmacol 2008;23:201-9.

Macdonald S, Halliday J, MacEwan T, Sharkey V, Farrington S, Wall S, et al. Nithsdale schizophrenia surveys 24:sexual dysfunction: case-control study. Br J Psychiatry 2003;182:50-6.

Fan X, Henderson DC, Chiang E, Briggs LB, Freudenreich O, Evins AE, et al. Sexual functioning, psychopathology and quality of life in patients with schizophrenia. Schizophr Res 2007;94:119-27.

Ghadirian AM, Chouinard G, Annable L. Sexual dysfunction and plasma prolactin levels in neuroleptic-treated schizophrenic outpatients. J Nerv Ment Dis 1982;170:463-7.

Fujii A, Yasui Furukori N, Sugawara N, Sato Y, Nakagami T, Saito M, et al. Sexual dysfunction in Japanese patients with schizophrenia treated with antipsychotics. Prog Neuropsychopharmacol Biol Psychiatry 2010;34:288-93.

Knegtering H, Blijd C, Boks M. Sexual dysfunction and prolactin levels in patients using risperidone or olanzapine. Schizophr Res 2000;41:196.

La Torre A, Conca A, Duffy D, Giupponi G, Pompili M, Grozinger M. Sexual dysfunction related to psychotropic drugs: a critical review part II: antipsychotics. Pharmacopsychiatry 2013;46:201-8.

Patnaik S, Polimati H, Pragada R. Erectile dysfunction and its pharmacology: an overview. Asian J Pharm Clin Res 2017;10:17-23.

Shekar D, Vazir M, Kempanna B, Miryala S, Subedi A. Effect of yohimbine on clomipramine-induced sexual dysfunction in male rats. Asian J Pharm Clin Res 2017;10:92.

Dossenbach M, Dyachkova Y, Pirildar S, Anders M, Khalil A, Araszkiewicz A, et al. Effects of atypical and typical antipsychotic treatments on sexual function in patients with schizophrenia: 12-month results from the intercontinental schizophrenia outpatient health outcomes (IC-SOHO) study. Eur Psychiatry 2006;21:251-8.

Calabro RS, Marino S, Bramanti P. Sexual and reproductive dysfunction associated with antiepileptic drug use in men with epilepsy. Expert Rev Neurother 2011;11:887-95.

Published

01-02-2020

How to Cite

SHAKYA, B., T. BABU, M. SHAFI P., . V. TEJASRI, J. SEBASTIAN, S. MANOHAR J., and J. M. LUCCA. “A PILOT STUDY ON IDENTIFICATION AND MANAGEMENT OF DRUG INDUCED SEXUAL DYSFUNCTION: A COLLABORATIVE APPROACH BY CLINICAL PHARMACIST AND PSYCHIATRIST: IDENTIFICATION AND MANAGEMENT OF DRUG INDUCED SEXUAL DYSFUNCTION”. International Journal of Pharmacy and Pharmaceutical Sciences, vol. 12, no. 2, Feb. 2020, pp. 32-37, doi:10.22159/ijpps.2020v12i2.34334.

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