DRUG RESISTANCE PATTERNS OF CLINICAL ISOLATES OF STAPHYLOCOCCUS AUREUS IN TERTIARY CARE CENTER OF SOUTH INDIA

Authors

  • Metri Basavaraj C Associate professor, Department of Microbiology, BLDEU’s Shri B M Patil Medical college, Bijapur Karnataka
  • Peerapur B. V. Professor and HOD, Department of Microbiology, RIMS-Raichur
  • P Jyothi Assistant professor, Department of Microbiology, BLDEU’s Shri B M Patil Medical college, Bijapur, Karnataka

Keywords:

Antibiotic susceptibility pattern, Drug resistance, Methicillin resistant Staphylococcus aureus (MRSA), antibiotic resistance, Staphylococcus aureus

Abstract

Objectives: Staphylococcus aureus were initially described in 1961 and emerged in the last decade as one of the most important nosocomial pathogens. The current study was undertaken to provide data for empirical selection of appropriate antibiotics for the treatment of diseases caused by S. aureus.

Methods: Various clinical samples like pus, urine, stool, sputum, blood and other body fluids of patients were selected for study from June 2012 to June 2013. Staphylococcus aureus were identified by various biochemical tests and antimicrobial susceptibility testing of the isolates were performed by Kirby Bauer disc diffusion method. Detection of the MRSA was done by Oxacillin disc diffusion method.

Results: A total of 137 isolates of S. aureus were obtained over duration of 12 months. These included isolates from the sample of pus, urine, sputum, body fluids. Out of 137 S. aureus strains isolated, 62 (45.3%) were identified as MRSA and 75 (54.7%) were identified as MSSA based on oxacillin disk diffusion method. Anti-biograms revealed the high level of resistance among MRSA isolates when compared to MSSA isolates The most effective agent against MRSA isolates was linezolid (96.8%sensitive), followed by tetracycline (90.9%) and piperacillin/tazobactam (80.6%).

Conclusion: The prevalence of MRSA in our hospital was high. Therefore to reduce the incidence of infections due to MRSA, we suggest implementation of the strict antibiotic policy guidelines and continuous monitoring of antibiotic susceptibility patterns of such pathogens.

 

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Author Biography

Metri Basavaraj C, Associate professor, Department of Microbiology, BLDEU’s Shri B M Patil Medical college, Bijapur Karnataka

  1. DR METRI  BASAVARAJ C *  M.D.

     Associate professor

     Department of Microbiology

                       BLDEU’s Shri B M Patil Medical college

                       Bijapur –Karnataka-586103                       

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Published

01-07-2015

How to Cite

C, M. B., P. B. V., and P. Jyothi. “DRUG RESISTANCE PATTERNS OF CLINICAL ISOLATES OF STAPHYLOCOCCUS AUREUS IN TERTIARY CARE CENTER OF SOUTH INDIA”. International Journal of Pharmacy and Pharmaceutical Sciences, vol. 7, no. 7, July 2015, pp. 70-72, https://www.innovareacademics.in/journals/index.php/ijpps/article/view/3603.

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