EFFECT OF MENTHA PIPERATA IN EXPERIMENTAL PROSTATIC HYPERPLASIA IN WISTAR ALBINO RATS
Keywords:
Benign prostatic hyperplasia, Dihydrotestosterone, Menthapiperata, Prostate gland, TestosteroneAbstract
Objective: To investigate the protective efficacy of Mentha piperata in experimental benign prostatic hyperplasia in Wistar albino rats.
Methods: Benign hyperplasia of prostate was induced by subcutaneous injection of testosterone (5mg/kg) daily for 28 days. Rats were divided into five groups (six rats each). A negative control group received subcutaneous arachis oil (1 ml/kg), Four groups were injected testosterone and divided into reference group (finasteride 1mg/kg), modelgroup(testosterone), study group A (M. piperata200mg/kg) and study group B (M. piperata 400mg/kg). On day 29, rats were sacrificed and body weight, prostate weight, bladder weight, testes weight, serum testosterone and total protein in prostate were measured and histopathological studies carried out. All results were expressed as mean ± SEM. Data were analysed by one-way analysis of variance followed by Tukey'spost hoc test.
Results: M. piperata(400mg/kg) significantly inhibited prostate growth and total protein content(P <0.05). The extract did not have significant effect on serum testosterone level, weight of testes and bladder. Histopathological analysis of prostate gland correlated with the above results.
Conclusion: Beneficial effects of M piperata in various common ailments have been proven through various studies. The findings of this study suggest a possible beneficial effect of Menthapiperata in the prevention of benign hyperplasia of prostate.
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