• PALANISAMY SIVANANDY Department of Pharmacy Practice, International Medical University, Kuala Lumpur 57000, Malaysia
  • AIDIL NATASHA ROSMAN School of Pharmacy, International Medical University, Kuala Lumpur 57000, Malaysia
  • AINAA DIYANA SHAPHERI School of Pharmacy, International Medical University, Kuala Lumpur 57000, Malaysia
  • TENG TENG CHEW School of Pharmacy, International Medical University, Kuala Lumpur 57000, Malaysia
  • NATALIE JIA XIN LAU School of Pharmacy, International Medical University, Kuala Lumpur 57000, Malaysia
  • MICHELLE ZI YIN YEONG School of Pharmacy, International Medical University, Kuala Lumpur 57000, Malaysia
  • MICHELLA ONG School of Pharmacy, International Medical University, Kuala Lumpur 57000, Malaysia
  • BIBI MUNIIRAH UMMEH HAANI MEETOOA School of Pharmacy, International Medical University, Kuala Lumpur 57000, Malaysia
  • ELAINE NG School of Pharmacy, International Medical University, Kuala Lumpur 57000, Malaysia
  • KARTHIKAYINI KRISHNASAMY Department of Nursing, University Malaya Medical Centre, Kuala Lumpur 59100, Malaysia
  • ARULKUMARAN GOVINDARAJAN Department of Pharmaceutics, KMCH College of Pharmacy, Kovai Estate, Kalapatti, Coimbatore 641048, Tamil Nadu, India
  • AKILA SHANMUGASUNDARAM Assistant Professor, Department of Physical Education, Bharathiar University, Coimbatore 641046, Tamil Nadu, India



Headache, Migraineurs, Nausea, Safety, Tolerability, Phonophobia


Migraine is a recurrent throbbing or pulsing headache with moderate to severe pain intensity. The pain is often one side of the head with nausea and weakness symptoms. Around 12 percent of Americans, 9 percent of Asians experiences migraine and the prevalence is highest among South Koreans (22.3%). The outcome of chronic migraine treatment can be quite disheartening, causing patients to feel out of options who have tried multiple treatments with no results. Poor efficacy, tolerability and safety of migraine preventive therapy in clinical practice lead to poor compliance and failure of therapy. The mean change in number or frequency of headache is considered as the outcome measure of migraine prevention therapy. Upon comparing all migraine prevention therapy, the Fremanezumab, Eptinezumab, Galcanezumab and Erenumab were considered as the front runner in controlling the severity and frequency of migraine. Among these drugs, Erenumab was most effective in controlling the frequency of migraine episodes as it produces more than 50 percent reduction in the mean number of monthly migraine days (MMD) over week 9-week 12. In addition to drug therapy, adequate rest, balanced diet, yoga and meditation will help patients to get rid of migraine severity. A multi-dimensional approach is essential for better control over migraine symptoms.


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How to Cite

SIVANANDY, P., A. N. ROSMAN, A. D. SHAPHERI, T. T. CHEW, N. J. X. LAU, M. Z. Y. YEONG, M. ONG, B. M. U. H. MEETOOA, E. NG, K. KRISHNASAMY, A. GOVINDARAJAN, and A. SHANMUGASUNDARAM. “COMPARISON OF EFFICACY AND SAFETY OF NEWER DRUGS APPROVED FOR THE TREATMENT OF MIGRAINE DISORDER: A REVIEW”. International Journal of Pharmacy and Pharmaceutical Sciences, vol. 12, no. 7, July 2020, pp. 1-9, doi:10.22159/ijpps.2020v12i7.37440.



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