• Renuka Srihari Maharani Lakshmi Ammanni College for Women
  • Austin Richard Surendranath University of Mysore
  • Nandashree Kasturacharya Maharani Lakshmi Ammanni College for Women
  • Karigar Chandrakanth Shivappa Tumkur University
  • Niranjali Devaraj Sivasitambaram University of Madras
  • Bhadrapura Lakkappa Dhananjaya Toxinology/Toxicology and Drug Discovery Unit, Centre for Emerging Technologies (CET), Jain University, Kanakpura Taluk, Ramanagara 562112, India


Aleo vera, Anticancer, Breast cancer, Cytotoxic, Antraquninones, Drugs


Objective: Breast cancer is the second leading cause of death among cancer pateints. Ayurvedic system of traditional medicine validated the use of plants as a useful source for occurrence of anticancer compounds. This study was attempted to investigate the in vitro anti-cancer potential of methanolic extract of Aleo vera on breast cancer MCF-7 cell lines.

Methods: The methanol extract of Aleo vera was screened for its anti-proliferative effect against MCF-7 (Breast cancer) cell lines seeded on 96 well plates.

Results: MCF-7 cells were treated with the extract for 24h and 72h at a range of increasing concentrations (0-500μg/ml) in order to obtain a dose-response graph and IC50 value. The Aleo vera extract showed cytotoxic effect in MCF-7cells with IC50 of 74.33 μg/ml.

Conclusion: The Aleo vera extract showed effective cytotoxic activity in a dose and time dependent manner. Future investigations will be interesting to find an active principle and also better understand its mechanism of action against cancer.



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How to Cite

Srihari, R., A. R. Surendranath, N. Kasturacharya, K. C. Shivappa, N. D. Sivasitambaram, and B. L. Dhananjaya. “EVALUATING THE CYTOTOXIC POTENTIAL OF METHONOLIC LEAF EXTRACT OF ALEO VERA ON MCF-7 BREAST CANCER CELL LINES”. International Journal of Pharmacy and Pharmaceutical Sciences, vol. 7, no. 13, Oct. 2015, pp. 81-83, https://www.innovareacademics.in/journals/index.php/ijpps/article/view/4020.