COMPARATIVE EVALUATION OF XANTHAN, GUAR AND TREATED GUAR GUMS AS DRUG RELEASE BARRIERS IN ORAL MATRICES
Objective: This study addresses comparative efficiency of three natural gums, namely, xanthan gum, guar gum and thermally treated guar gum, as drug release barriers for sparingly and free water soluble model drugs.
Methods: guar gum, xanthan gum or thermally primed treated guar gum (as matrix forming gum) were each used with microcrystalline cellulose (as supportive polymer) and either Propranolol-HCl, as a water soluble drug or Diclofenac-Na, as a water insoluble drug, to produce a series of matrix formulations using direct compression. Matrices were then qualified for friability, hardness, and drug release attributes.
Results: With an exception to guar gum based matrices which measures very low hardness, all matrices were found within the acceptable limit or criteria for friability and hardness. Guar gum demonstrated more ability to sustain the release of loaded drugs as compared to other gums. Although both drug solubility and gum type were shown to influence drug release profiles of investigated matrices, only drug solubility demonstrated to affect the kinetics of drug release, especially with xanthan gum matrices.
Conclusion: Compared to treated guar and xanthan gums, guar gum can be effectively used to fabricate sustained release matrices for both water soluble and insoluble drugs.
Keywords: Guar gum, Treated guar gum, Xanthan gum, Matrices, Propranolol-HCl, Diclofenac-Na.
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