A GLOBAL COMPARISON AND ANALYSIS OF NEURAMINIDASE H1N1 STRAIN OF INFLUENZA A
Keywords:
Influenza, Neuraminidase, Glycosylation, VaccineAbstract
Objective: To evaluate the variation of neuraminidase (NA) protein from various H1N1 strain for drug designing.
Methods: In this study we have used 12 sequences of NA protein from various countries, retrieved from UniprotKB database. We have performed structural analysis, antigenic and glycosylation site prediction between NA proteins of influenza A strains.
Results: Antigenic variants in sequence of NA H1N1 strain from Italy were found to be unique and were not present in any other NA H1N1. Strains from Italy and Thailand were found to be distantly related while others are closely related. We observed the maximum similarity from position 84 to 448 using disorder prediction analysis of different strains. Sequences from 1 to 83 and 449 to 469 showed the maximum dissimilarity among the NA Proteins.
Conclusion: This study focuses on the regions of sequence similarity and dissimilarity of NA in H1N1 strains from different countries. The results in this paper are based on currently available sequences for NA of H1N1 strains and bioinformatic tools. Our study will help in understanding of the regions of high variability due to mutations and conserved domains that can be potential targets for drug development.
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