THE ROLE OF HONEY WITH ROYAL JELLY IN PROTECTING THE GRAAFIAN FOLLICLES FROM THE TOXICITY OF THE ADRIAMYCIN DRUG
Keywords:
Adriamycin, Graafian follicles, Honey, Royal jelly, Syrian hamsterAbstract
Objective: This study aims to investigate the ability of certain mixture of honey with royal jelly (H+R) to prevent the toxic side effects, caused by the Adriamycin drug. One of the most important side effects of this drug is the change in the structure of cell and tissue of the ovary, especially Graafian follicles, which may lead to sexual ovarian hormonal disorders. Consequently, this will lead to menstrual disorders that lead in certain cases to early menopause (infertility), and decrease in the reproductive capacity.
Methods: Twenty-five young adult female Syrian hamsters were injected with (60-75 mg/m2 (Aderiamycin drug and another twenty-five females were injected with Adriamycin drug after oral administration with preventive dose of honey and royal jelly (800 mg/kg/day of Honey and 10 mg/kg/day of royal jelly). Histologically study of the ovaries was conducted with hymatoxylin & eosin staining, and an immunohistochemical study was applied using the immune. (Ki67) specialized for disclosure of cell divisions.
Results: The honey with royal jelly has a clear role in renovating the ovary, enhancing the hormonal balance, and prevents the hormonal disorders, and the occurrence of early menopause caused by Adriamycin.
Conclusion: The Honey with royal jelly contributes, as a preventive dose, in preventing the side effects of Adriamycin drug.
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References
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