• Edwin Marin University of Antioquia
  • John Rojas University of Antioquia


Poly (vinyl) alcohol, Glutaraldehyde, Cross linking, Waterproof, Film, Dip- coating


Objective: The purpose of this work is to cross link PVA with glutaraldehyde to develop new films with increased waterproof properties.

Methods: Cross linking of PVA with glutaraldehyde was conducted at 70°C at a 1:10 and 1:5 PVA: glutaraldehyde ratios. pH and reaction times of 5.5 and 6.5 and 1 and 6h were employed, respectively. The resulting films were analyzed for Cross linking degree, crystallinity, water sorption, swelling, contact angle, and tablet water uptake when stored for 45 days at 100% relative humidity.

Results: Reactions conducted at a pH of 5.5 rendered the largest Cross linking degrees. Cross linked films were less crystalline, flexible and hydrophilic. Further, they had a lower ability to swell and uptake water than the parent PVA. Moreover, compacts stored for 45 days and coated with cross linked films had a low water sorption ability than those coated with non-crosslinked PVA.

Conclusion: Cross linking of PVA with glutaraldehyde rendered films with a tight polymeric network, a reduced hydrogen bonding capacity, more hydrophobicity, and better waterproof properties in compacts containing hydro labile drugs.



Download data is not yet available.


Siepmann J, Siegel RA, Rathbone MJ, eds. Fundamentals and applications of controlled release drug delivery; 2012. p. 489.

Wise D. Handbook of pharmaceutical controlled release technology. Marcel Dekker Inc: New York; 2000. p. 891.

Marín E, Rojas J, Ciro Y. Polyvinyl alcohol derivatives: promising materials for pharmaceutical and biomedical applications. Afr J Pharm Pharmacol 2014;8:674-84.

Gift AD, Luner PE, Luedeman L, Taylor LS. Manipulating hydrate formation during high shear wet granulation using polymeric excipients. J Pharm Sci 2009;12:4670-83.

Hassan CM, Peppas NA. Structure and applications of poly (vinyl) alcohol hydrogels produced by convenctional Cross linking or by freezing/thawing methods. Adv Poly Sci 2000;153:37-65.

Bolto B, Tran T, Hoang M, Xie Z. Crosslinked poly (vinyl alcohol) membranes. Progr Polym Sci 2009;34:969-81.

Gohil J, Bhattacharya, Ray P. Studies on the cross-linking of poly (vinyl) alcohol. J Polym Res 2006;13:161-9.

Zhang Y, Zhu P, Edgren D. Cross linking reaction of poly (vinyl alcohol) with glyoxal. J Polym Res 2010;17:725-30.

Mansur H, Sadahira C, Souza A, Mansur A. FTIR spectroscopy characterization of poly (vinyl alcohol) hydrogel with different hydrolysis degree and chemically with glutaraldehyde. Mat Sci Eng C 2008;28:539-48.

Van den Berg C. Description of water activity of foods for engineering purposes by means of the GAB model of sorption. Eng Food 1984;1:311-21.

Rojas J. Excipient functionality enhancement: The cellulose II Case. Lambert Academic Publishing; 2012. p. 137.

Gebben B, Van der Berg H, Bargeman D. Intramolecular crosslink of poly (vinyl) alcohol. PolymJ 1985;26:1737-40.

Finch CAJ. Polyvinyl alcohol developments. Willey and Sons: New York; 1992. p. 850.

Sing KSW. Adsorption methods for the characterization of porous materials. Adv Colloid Interface Sci 1998;76-77:3-11.

Rouquerol F, Rouquerol J, Sing K. Adsorption by powders and porous solids, Academic Press: London, Great Britain; 1999. p. 626.



How to Cite

Marin, E., and J. Rojas. “PREPARATION AND CHARACTERIZATION OF CROSSLINKED POLY (VINYL) ALCOHOL FILMS WITH WATERPROOF PROPERTIES”. International Journal of Pharmacy and Pharmaceutical Sciences, vol. 7, no. 3, Mar. 2015, pp. 242-8,



Original Article(s)