ANTIDIABETIC AND HYPOLIPIDEMIC EFFECT OF FICUS RACEMOSA PETROLEUM ETHER EXTRACT IN STREPTOZOTOCIN INDUCED DIABETIC ALBINO RATS
Keywords:
Ficus racemosa, Streptozotocin, Antidiabetic, HypolipidemicAbstract
Objective: The present study was undertaken to evaluate the antidiabetic, hypolipidemic and toxic effects of petroleum ether extract of FR (PEFR) using streptozotocin (STZ) induced diabetic rats.
Methods: Diabetes was induced by administration of STZ (50 mg/kg) intraperitonially (i. p.) to albino rats. PEFR was administered once in a day for a period of seven days at doses of 100, 200 and 300 mg/kg according to body weight. Blood glucose and body weight changes were measured at different (1st, 3rd, 5th, and 7th) days of experiment. Serum lipid profile (TC, TG, LDL, VLDL, and HDL) and serum hepatic biomarker enzymes (SGOT and SGPT) levels were measured, and various antioxidant parameters in liver and pancreas were also determined at the end of experiment.
Results: Our results collectively suggested that oral administration of PEFR significantly reduced blood glucose level and restored body weight. This extract also reduced serum cholesterol, triglycerides, LDL, VLDL and improved HDL as compared with diabetic control group, signified hypolipidemic action. It increased glutathione and various enzyme levels (catalase and superoxide dismutase) in the pancreas at the same time. Various oxidative stress parameters like thiobarbituric acid reactive substances and protein carbonyl levels in liver were decreased after PEFR administration with respect to diabetic control rats.
Conclusion: PEFR possessed antidiabetic, antioxidant and hypolipidemic activities in STZ induced diabetic rats, which supported the use of FR as a food supplement for future drug design perspective.
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