PHARMACOLOGICAL EVALUATION OF RHIZOMES OF ACORUS CALAMUS FOR ANALGESIC ACTIVITY

Authors

  • Navneet Khurana School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab
  • Pushpendra Kumar Jain Adesh Institute of Pharmacy and Biomedical Sciences, Adesh University, Bathinda, Punjab
  • Yogesh Pounikar Sardar Patel College of Technology
  • Neha Sharma Shaheed Bhagat Singh College of Pharmacy

Keywords:

Acorus calamus, Analgesic activity, Hot plate method

Abstract

Objective: To evaluate the analgesic activity of aqueous extract of rhizomes of Acorus calamusin mice.

Methods: Analgesic activity of aqueous extracts of A. calamus at different doses were studied using the hot plate method. The study was carried out at three different dose levels (5, 25 and 50 mg/kg) ofA. calamus, given subcutaneously to mice.

Results: The different dose of aqueous extracts of A. calamus showed dose and time dependent analgesic effect and maximum effect was observed at 50 mg/kg dose of extract after 90 min of administration, which was comparable to diclofenac sodium, used as standard drug in the study.

Conclusion: The aqueous extract of rhizomes of A. calamuswas found to be effective analgesic in mice using the hot plate method. This study merits further detailed pharmacological investigation of this extract as well as isolation and characterization of its bioactive chemical constituents (s).

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Author Biographies

Navneet Khurana, School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab

Assistant Professor, Department of Pharmacology

Pushpendra Kumar Jain, Adesh Institute of Pharmacy and Biomedical Sciences, Adesh University, Bathinda, Punjab

Assistant Professor, Department of Pharmacology

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Published

01-04-2015

How to Cite

Khurana, N., P. K. Jain, Y. Pounikar, and N. Sharma. “PHARMACOLOGICAL EVALUATION OF RHIZOMES OF ACORUS CALAMUS FOR ANALGESIC ACTIVITY”. International Journal of Pharmacy and Pharmaceutical Sciences, vol. 7, no. 4, Apr. 2015, pp. 411-3, https://www.innovareacademics.in/journals/index.php/ijpps/article/view/5026.

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Section

Short Communication(s)