THE METAL COMPLEXES OF 1-(PHENYLAMINO)-4, 4, 6-TRIMETHYL-3, 4-DIHYDROPYRIMIDINE-2-(1H)-THIONE: PREPARATION, PHYSICAL, SPECTROSCOPIC STUDIES AND ANTIBACTERIAL PROPERTIES

Authors

  • Rajshree Khare Department of Chemistry, Maharishi Markandeshwar University, Mullana, Ambala 133207, Haryana, India
  • Pooja Sethi Department of Chemistry, Maharishi Markandeshwar University, Mullana, Ambala 133207, Haryana, India

Keywords:

Synthesis, Pyrimidine-2-(1H)-thione, Antibacterial activity, Thermal study

Abstract

Objective: The metal complexes of 1-(Phenylamino)-4, 4, 6-trimethyl-3, 4-dihydropyrimidine-2-(1H)-thione: preparation, physical and spectroscopic studies and preliminary antibacterial properties.

Methods: Complexes of bidentate ligand containing N, S-bridge [M(pmpt)2(H2O)n] (M(II) = Cu, Mn, Ni, Co; n = 2 and M(II) = Zn, Cd, Pd; n = 0) derived from the reaction of Hpmpt ligand with metals (M(II) = Cu, Mn, Ni, Co, Zn, Cd, Pd) and characterized by various physico-chemical techniques. From magnetic moment studies, square planar geometry is suggested for Zn(II), Cd(II), Pd(II) complexes, octahedral geometry is proposed for Co(II), Ni(II) and Mn(II) and distorted octahedral for Cu(II) complexes. Thermo gravimetric (TG) curves indicate the decomposition of complexes in four to five steps. The presence of coordinated water in metal complexes was confirmed by thermal, elemental analysis and IR data. Free ligand and its complexes were assayed in vitro for their antibacterial activity against gram positive and gram negative bacteria using chloramphenicol as a standard market-drug.

Results: The reported complexes were synthesized through greener protocol that is grindstone method by mixing the ligand and metal salts in 2:1 molar ratio. Products were obtained in good yield with sharp melting point.

Conclusion: Studies have indicated that such complexes can be prepared by environment friendly approach which requires less time, simple workup for isolation and purification with good yield. The [Ni(pmpt)2(H2O)2] complex showed excellent antibacterial activity while other reported metal complexes showed weak antibacterial activity.

 

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Author Biography

Rajshree Khare, Department of Chemistry, Maharishi Markandeshwar University, Mullana, Ambala 133207, Haryana, India

Dr.Rajshree Khare(Prof and Head)

Department of Chemistry

New Engineering Block-2

M.M.U, Ambala

India

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Published

01-07-2015

How to Cite

Khare, R., and P. Sethi. “THE METAL COMPLEXES OF 1-(PHENYLAMINO)-4, 4, 6-TRIMETHYL-3, 4-DIHYDROPYRIMIDINE-2-(1H)-THIONE: PREPARATION, PHYSICAL, SPECTROSCOPIC STUDIES AND ANTIBACTERIAL PROPERTIES”. International Journal of Pharmacy and Pharmaceutical Sciences, vol. 7, no. 7, July 2015, pp. 434-40, https://www.innovareacademics.in/journals/index.php/ijpps/article/view/5330.

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