SYNTHESIS, FREE RADICAL SCAVENGING AND DNA CLEAVAGE ACTIVITIES OF SOME NOVEL INDOLE DERIVATIVES
Keywords:
Indolyl chalcones, Thiobarbituric acid, Free radical scavenging activity, DNA cleavage activityAbstract
Objective: Synthesis of a series of novel indole derivatives (6a-h) by condensation of indolyl chalcones (5a-h) with thiobarbituric acid to evaluate free radical scavenging and DNA cleavage activity.
Methods: The newly synthesized compounds were screened for free radical scavenging activity by DPPH method. The DNA cleavage activity of some indole derivatives was studied by agarose gel electrophoresis method. The structures of the synthesized compounds are assigned on the basis of elemental analysis, IR, 1HNMR, 13C NMR and mass spectral data.
Results: Among the synthesized compounds the simple indole derivative (6a) has very good scavenging activity, chloro and fluoro substituted indole derivatives (6g), (6h) have shown moderate activities and methyl derivatives (6e), (6f) have shown least activity compare with the standard. All the tested compounds in the series have exhibited promising DNA cleavage activity.
Conclusion: A series of novel indole derivatives were synthesized and evaluated for free radical scavenging and DNA cleavage activity. The compound (6g) was found most active among all the synthesized compounds.
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