PHARMACOKINETIC STUDIES OF NEW SILVER-BASED COMPLEX

Authors

  • Vladimir Silnikov Institute of Chemical Biology and Fundamental Medicine, Novosibirsk, Russia
  • Evgenii Plotnikov Tomsk Polytechnic University
  • Vladimir Plotnikov Tomsk Polytechnic University

Keywords:

Silver-based complex, Pharmacokinetics, Antiviral drug, Silver distribution in tissues, Mass spectrometry, Argosil

Abstract

Objective: Investigation of pharmacokinetics parameters of the new silver-based compound of general formula C6H19Ag2N4LiO6S2, called Argosilâ€, with high antiviral activity.

Methods: Water solution of complex administered intragastrically in the dose rate of 100 mg/kg body weight of mice BALB/c (males) aged 1.5-2.0 mo. Blood and tissues samples analyzed by mass spectrometry.

Results: Half-life of the drug was about 4 h at the initial stage. About 5% of the initially introduced silver detected after 24 h. Maximum drug concentration observed in the lung tissues.

Conclusion: Results make the basis for further test and clinical implementation. Taken into account low toxicity and antiviral properties of this compound, it looks especially effective for lung infections treatment.

 

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Author Biography

Evgenii Plotnikov, Tomsk Polytechnic University

analytical chemistry department

ORCID: 0000-0002-4374-6422

References

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Tikhonov VL, Donchenko AS, Glotovo TI, Silnikov VN, Tretyakov VV. Toxicity and antiviral activity of the new drug on the basis of silver Argobiotsin-2S. Siberian herald agricultural science (Rus) 2007;12:55-60.

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Solovyev VN, Firsov AA, Filobbb v VA. Pharmacokinetics. Moscow: Medicine; 1980. p. 424.

Khabriev RW. Manual on experimental (preclinical) study of new pharmacological substances. Moscow: Medicine; 2005. p. 832.

Published

01-06-2015

How to Cite

Silnikov, V., E. Plotnikov, and V. Plotnikov. “PHARMACOKINETIC STUDIES OF NEW SILVER-BASED COMPLEX”. International Journal of Pharmacy and Pharmaceutical Sciences, vol. 7, no. 6, June 2015, pp. 41-43, https://www.innovareacademics.in/journals/index.php/ijpps/article/view/5396.

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Section

Original Article(s)