ANTIEPILEPTIC ACTIVITY OF SOME NOVEL SUBSTITUTED FLUORO BENZOTHIAZOLE DERIVATIVES

Authors

  • Shanmukha I PG Dept of Pharmacology, SCS College of Pharmacy, Harapanahalli, Davangere 583131 Karnataka,
  • Vijay Kumar M PG Dept of Pharmacology, SCS College of Pharmacy, Harapanahalli, Davangere 583131 Karnataka,
  • Jayachandran E PG Dept of Pharmacology, SCS College of Pharmacy, Harapanahalli, Davangere 583131 Karnataka,
  • Revanasiddappa B C Dept of Pharmaceutical Chemistry, NGSM Institute of Pharmaceutical Sciences. Paneer, Deralakatte, Mangalore 575018 Karnataka, India

Keywords:

Antiepileptic activity, MES, Fluoro substituted benzothiazole derivatives

Abstract

Objective: The aim of the study is to investigate and to reveal the antiepileptic activity of fluoro substituted benzothiazole derivatives (FBTDs) in experimental induced epilepsy in mice.

Methods: The acute oral toxicity was determined as per OECD guideline 423 and minimum effective dose was also determined for pharmacological screening. The antiepileptic activity of FBTDs was studied against maximal electroshock (MES) and strychnine (1 mg/kg, s. c.) induced seizures in mice.

Results: In MES test, the duration of tonic hind limb extension was significantly reduced by all FBTDs at a dose of 100 mg/kg except, P-3, and OX-9 whereas in strychnine induced model, the seizure latency was sustained by all FBTDs at a dose of 100 mg/kg except P-4. P-7 and OX-9.

Conclusion: The novels synthesized FBTDs shown very good activity and lead a route for further studies in this particular molecule.

 

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Author Biography

Shanmukha I, PG Dept of Pharmacology, SCS College of Pharmacy, Harapanahalli, Davangere 583131 Karnataka,

P.G Dept. of Pharmacology

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Published

01-07-2015

How to Cite

I, S., V. K. M, J. E, and R. B. C. “ANTIEPILEPTIC ACTIVITY OF SOME NOVEL SUBSTITUTED FLUORO BENZOTHIAZOLE DERIVATIVES”. International Journal of Pharmacy and Pharmaceutical Sciences, vol. 7, no. 7, July 2015, pp. 157-9, https://www.innovareacademics.in/journals/index.php/ijpps/article/view/5471.

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