ANTIEPILEPTIC ACTIVITY OF SOME NOVEL SUBSTITUTED FLUORO BENZOTHIAZOLE DERIVATIVES
Keywords:Antiepileptic activity, MES, Fluoro substituted benzothiazole derivatives
Objective: The aim of the study is to investigate and to reveal the antiepileptic activity of fluoro substituted benzothiazole derivatives (FBTDs) in experimental induced epilepsy in mice.
Methods: The acute oral toxicity was determined as per OECD guideline 423 and minimum effective dose was also determined for pharmacological screening. The antiepileptic activity of FBTDs was studied against maximal electroshock (MES) and strychnine (1 mg/kg, s. c.) induced seizures in mice.
Results: In MES test, the duration of tonic hind limb extension was significantly reduced by all FBTDs at a dose of 100 mg/kg except, P-3, and OX-9 whereas in strychnine induced model, the seizure latency was sustained by all FBTDs at a dose of 100 mg/kg except P-4. P-7 and OX-9.
Conclusion: The novels synthesized FBTDs shown very good activity and lead a route for further studies in this particular molecule.
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