• Gaganpreet Kaur Department of Pharmaceutics, Lovely Faculty of Applied Medical Sciences, Lovely Professional University, Jalandhar-Delhi G. T. Road (NH-1),
  • K. Prabhudas Kiran Department of Pharmaceutics, Lovely Faculty of Applied Medical Sciences, Lovely Professional University, Jalandhar-Delhi G. T. Road (NH-1),
  • Amit Singh Department of Pharmaceutics, Lovely Faculty of Applied Medical Sciences, Lovely Professional University, Jalandhar-Delhi G. T. Road (NH-1),


Mucoadhesive, Natural polymers, Microbeads, Sustained release, Theophylline


Objective: The aim of present study was to develop and evaluate mucoadhesive microbeads for oral sustained release of an antiasthmatic agent theophylline†using natural gums such as sodium alginate and sesbania gum.

Methods: The compatibility studies of drug with different polymers were investigated by using DSC (Differential Scanning Calorimeter) and FTIR (Fourier Transform Infrared Spectroscopy). Carbohydrate heteropolymer microbeads of alginate and sesbania gums were prepared by ionotropic gelation technique, where calcium chloride is used as a source of counter ions. Prepared beads were characterized for particle size, entrapment efficiency, surface morphology, swelling index, in vitro release studies and release kinetics.

Results: Final optimized formulation consists of a polymer blend of alginate and sesbania gum with hydroxy propyl cellulose as release modifier. Microbeads exhibited good swelling index and high percentage of drug entrapment efficiency. The developed formulation showed a maximum drug release of 92% in 11 h using 0.1 N hydrochloric acid buffer (pH 1.2). The formulation followed Korsmeyer-Peppas and Higuchi release mechanism, releasing the drug by non-fickian diffusion. Prepared beads showed significant mucoadhesion in acidic buffer.

Conclusion: The sustained release microbeads were successfully designed for oral administration of theophylline which may be used for the treatment of nocturnal asthma.



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How to Cite

Kaur, G., K. P. Kiran, and A. Singh. “DEVELOPMENT OF MUCOADHESIVE CARBOHYDRATE HETEROPOLYMER MICROBEADS FOR SUSTAIN RELEASE OF THEOPHYLLINE”. International Journal of Pharmacy and Pharmaceutical Sciences, vol. 7, no. 7, July 2015, pp. 295-9,



Original Article(s)