ANTIHYPERGLYCEMIC AND ANTIDYSLIPIDEMIC POTENTIAL OF IPOMOEA BATATAS LEAVES IN VALIDATED DIABETIC ANIMAL MODELS

Authors

  • Savita Pal Division of Biochemistry, CSIR-Central Drug Research Institute, Jankipuram extension Lucknow 226031 (India)
  • Sudeep Gautam Division of Biochemistry, CSIR-Central Drug Research Institute, Jankipuram extension Lucknow 226031 (India)
  • Arvind Mishra Division of Biochemistry, CSIR-Central Drug Research Institute, Jankipuram extension Lucknow 226031 (India)
  • Rakesh Maurya Division of Medicinal and Process Chemistry, CSIR-Central Drug Research Institute, Jankipuram extension Lucknow 226031 (India)
  • Arvind K. Srivastava Division of Biochemistry, CSIR-Central Drug Research Institute, Jankipuram extension Lucknow 226031 (India).

Keywords:

Antidiabetic activity, Antidyslipidemic activity, Glucose uptake, STZ-induced rats, Neonatal STZ induced diabetic rats, Ipomoea batatas leaves

Abstract

Objective: The present study was undertaken to investigate the antidiabetic potential of the leaves of Ipomoea batatas.

Methods: The crude powder, 95% ethanolic, 50% ethanolic and aqueous extracts of Ipomoea batatas leaves were administered to normoglycemic and streptozotocin (STZ)-induced diabetic rats in a single dose study. The chloroform, butanol and aqueous fractions of aqueous extract were investigated for their antihyperglycemic on STZ-induced diabetic rats. Multiple dose study of an aqueous fraction was also done in STZ and neonatal STZ-induced diabetic rats. Further, the aqueous fraction was measured against the alpha glucosidase and aldose reductase enzymes, and glucose uptake in L6 myotubes.

Results: The aqueous extract showed significant lowering of postprandial hyperglycemia of post sucrose loaded normal rats and significantly declined the blood glucose level of STZ-induced diabetic rats. The aqueous fraction at a single dose of 100 mg/kg b. w in comparison with chloroform and butanol fractions significantly lowered the blood glucose level of STZ-induced diabetic rats. The aqueous fraction in a multiple dose study were found to significantly improved the percent glycated hemoglobin (%HbA1c), fasting blood glucose, oral glucose tolerance (OGTT), serum insulin, lipid profile, liver and kidney parameters in STZ-induced diabetic rats. Marked improvement in OGTT and serum insulin levels was also found in neonatal STZ-induced diabetic rats. In vitro study, the aqueous fraction of I. batatas increased glucose uptake in L6 myotubes and inhibits the α-glucosidase and aldose reductase enzymes.

Conclusion: The present study demonstrated the significant antidiabetic activity of the I. batatas leaves by promoting insulin secretion, alpha glucosidase and aldose reductase enzyme inhibition.

 

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Author Biography

Arvind K. Srivastava, Division of Biochemistry, CSIR-Central Drug Research Institute, Jankipuram extension Lucknow 226031 (India).

Senior Principal Scientist

Biochemistry Division

Council of Scientific and Industrial Research (CSIR)-Central Drug Research Institute (CDRI), Lucknow-226031, India

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Published

01-07-2015

How to Cite

Pal, S., S. Gautam, A. Mishra, R. Maurya, and A. K. Srivastava. “ANTIHYPERGLYCEMIC AND ANTIDYSLIPIDEMIC POTENTIAL OF IPOMOEA BATATAS LEAVES IN VALIDATED DIABETIC ANIMAL MODELS”. International Journal of Pharmacy and Pharmaceutical Sciences, vol. 7, no. 7, July 2015, pp. 176-8, https://www.innovareacademics.in/journals/index.php/ijpps/article/view/5603.

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