• Ganeshan V Department of Pharmaceutics, Erode College of Pharmacy, Erode
  • Ethiraj T Department of Pharmaceutics, Erode College of Pharmacy, Erode


Prulifloxacin, Cooling crystallization


Objective: Aim of this present study was to prepare and characterize the different polymorphs of Prulifloxacin using Powder X-Ray Diffraction analysis (PXRD), Scanning Electron Microscopy (SEM), Differential Scanning Calorimetry (DSC), Fourier Transform Infrared Spectrometry (FTIR) and dissolution studies.

Methods: Polymorphs of Prulifloxacin were prepared by cooling crystallization method using various solvents and they exhibited three different polymorphic forms that polymorph 1 (P-1), polymorph 2 (P-2) and polymorph 3 (P-3) with acetonitrile, acetone and dichloromethane.

Results: Rod shaped crystal obtained from acetone (P-2) showed the highest percentage drug release in dissolution study than other crystals due to smaller particle size. P-1 form showed higher melting point in thermogram due to more stability. Melting temperatures obtained from DSC graph indicate the existence of different crystal forms. Significant differences were found in FTIR studies. Appearance and disappearance of specific peaks on the PXRD pattern reveal that the formation of newer crystal forms.

Conclusion: It was concluded that the Prulifloxacin existed three polymorphic forms and they showed highest solubility and percentage drug release than amorphous form.



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Raul P, Venugopalan P. Polymorphism: an overview. J Sci Edu Resonance 2009;14(9):882-983.

Mange RY, Anwar RS, Ganesan V, Rajani G, Renu C. Studies on the crystal forms of Pefloxacin: Preparation, characterization and dissolution profile. J Pharm Sci 2008;97(7):2637-48.

Barbas R, Proens R, Cristina P. A new polymorph of Norfloxacin completes characterization and relative stability of its trimorphic system. J Therm Anal Calorim 2007;89(3):687-92.

Veerendra K, Nanjwade, Manvi FV, Shamrez AM, Meenaxi MM, Basavaraj K, et al. Development and characterization of novel pharmaceutical crystalline complex of Lomefloxacin. Int J Drug Dev Res 2012;4(1):227-33.

Antinio L, Jonathan C, Burley, Timothy J, Prior, Robert C, et al. Concomitant hydrate polymorphism in the precipitation of Sparfloxacin from aqueous solution. J Crystal Growth Design 2008;8(1):114-8.

Hiroaki K, Chisa W, Reimei M, Hideo H. Effect of dehydration on the formation of Levofloxacin pseudopolymorphs. Chem Pharm Bull 1995;43(4):649-53.

Nighute AB, Bhise SB. Preparation and evaluation of microcrystals of Cefuroxime axetil. Int J Pharm Tech Res 2009;1(3):424-30.



How to Cite

V, G., and E. T. “PREPARATION AND CHARACTERIZATION OF CRYSTALS OF PRULIFLOXACIN”. International Journal of Pharmacy and Pharmaceutical Sciences, vol. 7, no. 7, July 2015, pp. 307-10,



Original Article(s)