ANTI-INFLAMMATORY AND ANALGESIC ACTIVITY OF ARENGA WIGHTII GRIFF.-AN ENDEMIC PALM OF WESTERN GHATS

Authors

  • P Shikha Jawaharlal Nehru Tropical Botanic Garden and Research Institute, Palode, Thiruvananthapuram 695562, India
  • P G Latha Jawaharlal Nehru Tropical Botanic Garden and Research Institute, Palode, Thiruvananthapuram 695562, India
  • S R Suja Jawaharlal Nehru Tropical Botanic Garden and Research Institute, Palode, Thiruvananthapuram 695562, India
  • S Rajasekharan Jawaharlal Nehru Tropical Botanic Garden and Research Institute, Palode, Thiruvananthapuram 695562, India
  • G I Anuja Jawaharlal Nehru Tropical Botanic Garden and Research Institute, Palode, Thiruvananthapuram 695562, India

Keywords:

Anti-inflammatory, Carrageenan-induced paw oedema, Cotton pellet-induced granuloma, Acetic acid-induced vascular permeability, Acetic acid-induced writhing, Formalin induced nociception, Acetyl salicylic acid, Indomethacin

Abstract

Objective: The present study aims to scientifically validate the anti-inflammatory and analgesic activities of Arenga wightii.

Methods: The stem pith was excised from mature palm, sliced into small pieces, shade dried and powdered. The powder was extracted with ethanol, concentrated under reduced pressure and the crude extract was referred to as AW. The anti-inflammatory and analgesic activity of AW was analyzed in Wistar rats and Swiss albino mice.

Results: The results revealed that the ethanolic extract of the stem pith of A. wightii showed a dose dependent anti-inflammatory and analgesic activity, which was comparable to the standards, indomethacin and acetyl salicylic acid respectively.

Conclusion: The results of the current study reveal that A. wightii possesses significant anti-inflammatory and analgesic activity.

 

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References

Xiao-Li Wu, Chu-Wen Li, Hai-Ming Chen, Zu-Qing Su, Xiao-Ning Zhao, Jian-Nan Chen, et al. Anti-inflammatory effect of supercritical-carbon dioxide fluid extract from flowers and buds of Chrysanthemum indicum Linnen. Evidence-Based Complementary Altern Med 2013. DOI: 10.1155/2013/413237. [Article In Press].

Laine L. Approaches to nonsteroidal anti-inflammatory drug use in high risk patients. Gastroenterology 2001;120:594-606.

Lo V, Meadows SE, Saseen J. When could COX-2 selective NSAIDs be used for osteoarthritis and rheumatoid arthritis. J Family Practice 2006;55:260-2.

Ofman JJ, MacLean CH, Straus WL, Morton SC, Berger ML, Roth EA, et al. Metaanalysis of severe upper gastrointestinal complications of nonsteroidal anti-inflammatory drugs. J Rheumatol 2002;29:804-12.

Ling CQ, Chiu JH, Oh B, Cho WCS. Natural products for liver diseases: basic, clinical and translational research. Evid Based Complement Alternat Med 2012. DOI.org/10.1155/ 2012/794343. [Article In Press].

Johnson DV. Non wood forest products 10: Tropical Palms. Rome: Food and Agricultural Organisation of the United States (FAO); 1998.

Dennis J. Palm utilization and management in Asia: Examples for the Neotropics. Bulletin de l’Institut Françaisd’ Études Andines 1992;21(2):727-40.

Sasidharan N, Jomy A. Ethnobotany of the tribes living in and around the Periyar Tiger Reserve, Southern Western Ghats, India. J Economic Taxonomic Botany 2006;30:45-58.

Renuka C. Palms of Kerala. Kerala: Kerala Forest Research Institute, Peechi, Thrissur; 1999. p. 15-6.

Ambily DV, Rajith NP, George V, Pushpangadan P. Utilization of medicinal plants by the Paniyan tribe of Kozhikode district, Kerala. Ethnobotany 2010;22:14-24.

Udayan PS, Harinarayana MK, Tushar KV, Indira Balachandran. Some common plants used by the Kurichiar tribe in Tirunelli forest, Wayanad district, Kerala in medicine and other traditional uses. Indian J Traditional Knowledge 2008;7(2):250-5.

Ratheesh Narayanan MK, Anil Kumar N, Balakrishnan V. Uses of wild edibles among the paniya tribe in Kerala, India. In: Conservation and Sustainable Use of Agricultural Biodiversity-A Sourcebook. Published by CIP-UPWARD, in partnership with GTZ GmbH, IDRC of Canada, IPGRI and SEARICE; 2003. p. 101-8.

Nazarudeen A, Seeni S, Koshy KC, Pushpangadan P. Folk plants of food, medicine, adornment and repellent used by the paniyar community in North Kerala. J Economic Taxonomic Botany 1996;12:299-305.

Arinathan V, Mohan VR, John De Britto A, Murugan C. Wild edibles used by Palliyars of Western Ghats, Tamilnadu. Indian J Traditional Knowledge 2007;6(1):163-8.

Johncy M, Francis M. Arenga wightii Griff.–A unique source of starch and beverage for the Muthuvan tribe of Idukki district, Kerala. Indian J Traditional Knowledge 2007;6(1):195-8.

Winter CA, Risley EA. Carrageenan-induced edema in hind paw of the rat as an assay for anti–inflammatory drugs. Proc Soc Exp Biol Med 1962;111:544-7.

Ismail TS, Gopalakrishnan S, Begum VH, Elango V. Anti-inflammatory activity of Salacia oblonga Wall and Azima tetracantha Lam. J Ethnopharmacol 1997;56:145-52.

Whittle BA. The uses of changes in capillary permeability in mice to distinguish between narcotic and non-narcotic analgesics. Br J Pharmacol Chemother 1964;22:246-53.

Koster R, Anderson M. Acetic acid for analgesic screening. Fed Proc 1959;18:412.

Hunskaar S, Hole K. The formalin test in mice: dissociation between inflammatory and non-inflammatory pain. Pain 1987;30(1):103-14.

Tjolsen A, Berge OG, Hunskaar S, Rosland JH, Hole K. The formalin test: an evaluation of the method. Pain 1992;51(1): 5-17.

OECD/OCDE 423. Acute oral toxicity-acute toxic class method. OECD. OECD guidelines for testing of chemicals; 2001. p. 1-14.

Harborne JB. Phytochemical Methods. Second edition. London: Chapman and Hall; 1984. p. 9-15.

Trease GE, Evans WC. A textbook of Pharmacognosy. Eleventh edition. London: Bailliere Tindell Can. Macmillian Publishers; 1984.

Mitchell RN, Cotran RS. In: Robinson’s Basic Pathology. Seventh edition. New Delhi: Harcourt India Pvt. Ltd; 2000. p. 33-42.

Jain NK, Singh A, Kulkarni SK. Analgesic, anti-inflammatory and ulcerogenic activity of a Zinc-Naproxen complex in mice and rats. Pharm Pharmacol Commun 1995;5:599-602.

Winter CA, Porter CC. Effect of alteration in side chain on anti-inflammatory and liver glycogen activities of hydrocortisone esters. J Am Pharm Assoc Am Pharm Assoc (Baltim) 1957;46(8):515-9.

Thangam C, Dhananjayan R. Anti-inflammatory potential of the seeds of Carum copticum Linn. Indian J Pharmacol 2003;35:388–91.

Swingle KF. Anti-inflammatory agents, Chemistry and Pharmacology. Vol. 2. New York: Academic Press; 1974. p. 33–47.

Bhattacharya S, Pal S, Nag Choudhari AK. Pharmacological studies of the anti-inflammatory profile of Mikania cordata (Burm)B. L. Robinson root extract in rodents. Phytother Res 1992;6:255-60.

Swingle KF, Shideman FE. Phases of the inflammatory response to subcutaneous implantation of a cotton pellet and their modification by certain anti-inflammatory agents. J Pharmacol Exp Ther 1972;182:226-34.

Kavimani S, Vetrichelvan T, Ilango R, Jaykar B. Anti inflammatory activity of the volatile oil of Toddalia asiatica. Indian J Pharm Sci 1996;58(2):67-70.

Olugbenga M, Awe EO, Modupe Makinde J, Olajide AO. Evaluation of anti-inflammatory and analgesic properties of Chasmanthera dependens leaf methanol extract. Fitoterapia 2001;72:497-502.

Deraedt R, Jougney S, Delevalcee F, Falhout M. Release of Prostaglandin E and F in an algogenic reaction and its inhibition. Eur J Pharmacol 1980;51:17-24.

Ikeda Y, Ueno A, Naraba H, Oh-ishi S. Involvement of vanilloid receptor VRl and prostanoids in the acid-induced writhing responses of mice. Life Sci 2001;69:2911-9.

Collier HO, Dinneen LC, Johnson CA, Schneider C. The abdominal constriction response and its suppression by analgesic drugs in the mouse. Br J Pharmacol Chemother 1968;32(2):295-310.

Raj PP. Pain mechanisms. In: Pain Medicine: A Comprehensive Review. First edition. USA: Mosby-Year Book; 1996. p. 12-24.

Hunskaar S, Fasmer OB, Hole K. Formalin test in mice, a useful technique for evaluating mild analgesics. J Neurosci Methods 1985;14(1):69-76.

Murray CW, Porreca F, Cowan A. Methodological refinements in the mouse paw formalin test an animal model of tonic pain. J Pharmacol Methods 1988;20(2):175-86.

Dharmasiri MG, Jayakody JRAC, Galhena G, Liyanage SSP, Ratnasooriya WD. Antiinflammatory and analgesic activities of the mature fresh leaves of Vitex negundo. J Ethnopharmacol 2003;87:199-206.

Sankawa U, Chun YT. Anti-allergic substances from Chinese medicinal plants. In: Chang HM, Yeung HN, Tsu WW, Koo A. editors. Advances in Chinese Medicinal Materials Research. Singapore: World Scientific Publication Co; 1985. p. 171-80.

Ng TB, Ling JML, Wang ZT, Cai JN, Xu GJ. Examination of coumarins, flavonoids and polysaccharopeptides for antibacterial activity. Gen Pharmacol 1996;27:1237-40.

Narayana KR, Reddy MS, Chaluvadi MR, Krishna DR. Biflavanoids: Classification, pharmacology, biochemical effects and therapeutic potential. Indian J Pharmacol 2001;33:2-16.

Just MJ, Racio MC, Giner RM, Cuellar MJ, Manez S, Bilia AR, et al. Anti inflammatory activity of unusual lupine saponins from Bupleurum fruticescens. Planta Med 1998;64(5):404-7.

Published

01-07-2015

How to Cite

Shikha, P., P. G. Latha, S. R. Suja, S. Rajasekharan, and G. I. Anuja. “ANTI-INFLAMMATORY AND ANALGESIC ACTIVITY OF ARENGA WIGHTII GRIFF.-AN ENDEMIC PALM OF WESTERN GHATS”. International Journal of Pharmacy and Pharmaceutical Sciences, vol. 7, no. 7, July 2015, pp. 203-7, https://www.innovareacademics.in/journals/index.php/ijpps/article/view/5883.

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