HOMOCASTASTERONE: A NOVEL PLANT KETOSTEROID INDUCING HAEMATOLOGICAL CHANGES IN NORMAL AND DIABETIC MALE RAT

Authors

  • Athithan V Dept. of Biochemistry and Molecular Biology, School of Life Science, Pondicherry University, Pondicherry-605014, India.
  • Premalatha R Dept. of Biochemistry and Molecular Biology, School of Life Science, Pondicherry University, Pondicherry-605014, India.
  • Victor Mukherjee Dept. of Biochemistry and Molecular Biology, School of Life Science, Pondicherry University, Pondicherry-605014, India.
  • Mani N Dept. of Pathology, Indira Gandhi Government General Hospital and Postgraduate Institute, Puducherry-605001,India.
  • Srikumar K Dept. of Biochemistry and Molecular Biology, School of Life Science, Pondicherry University, Pondicherry-605014, India.

Keywords:

Homocastasterone, Oxysterol, Haematological parameters, Blood glucose, Lipid peroxidation

Abstract

Objective: To study the effect of brassinosteroid keto isoform homocastasterone, in diabetic male wistar rat as an antihyperglycemic factor and to evaluate its effects on the hemodynamic parameters in rat blood.

Methods: Diabetes was induced in a group (n=6) of rats with a single peritoneal injection of streptozotocin at 60 mg/kg. bw. With a treatment schedule of 15 consecutive days, control (n=6) and diabetic rats received 666µg/kg bw, of homocastasterone. Circulating blood glucose, cell count, cell indices, and MDA level was assessed.

Results: Significant reduction (p<0.05) in blood glucose level and increase inRBCs, WBCs, granulocytes, lymphocytes, monocytes and platelets count(p<0.05) along with improved functional indices for HCT, PCV, MCV, MCH, MCHC, MPV, PDW, PCT in homocastasterone treated diabetic group was noted. A significant reduction in RBC-MDA level (p<0.001) in the treated group was noted.

Conclusion: It is suggested that brassinosteroid keto isoform homocastasterone exhibits antiglycemic effect in diabetic rat, and improves RBC, WBC, Platelet counts, haemoglobin level, and cell indices, while reducing peroxidative cell damage in RBCs.

 

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Published

01-07-2015

How to Cite

V, A., P. R, V. Mukherjee, M. N, and S. K. “HOMOCASTASTERONE: A NOVEL PLANT KETOSTEROID INDUCING HAEMATOLOGICAL CHANGES IN NORMAL AND DIABETIC MALE RAT”. International Journal of Pharmacy and Pharmaceutical Sciences, vol. 7, no. 7, July 2015, pp. 125-8, https://www.innovareacademics.in/journals/index.php/ijpps/article/view/5980.

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