COMPARATIVE LC-MS STABILITY INDICATIND ASSAYS OF ONDANSETRON HYDROCHLORIDE/NALOXONE HYDROCHLORIDE AND METOCLOPRAMIDE HYDROCHLORIDE/NALOXONE HYDROCHLORIDE USED IN PALLIATIVE CARE

Authors

  • Naser F Altannak Assistant Professor, Department Of Pharmaceutical Chemistry Faculty Of Pharmacy, Kuwait University, P. O Box 23924, Safat, 13110 Kuwait

Keywords:

Palliative care-liquid chromatography-mass spectrometry-high performance liquid chromatography-ondansetron hydrochloride-metoclopramide hydrochloride-naloxone hydrochloride

Abstract

Objectives: To compare the compatibility and chemical stability of ondansetron hydrochloride/naloxone hydrochloride and metoclopramide hydrochloride/naloxone hydrochloride admixtures used in palliative care units at three different storage conditions (4ËšC, 22 ËšC and 37ËšC) for 192 hours.

Methods: A high performance liquid chromatography-mass spectrometry (LC-MS) analytical method was established to investigate the chemical stability of the combinations.

Results: Metoclopramide hydrochloride and naloxone hydrochloride concentrations remain above 90% of their initial concentration under all storage conditions for 192 hours, while ondansetron hydrochloride remain stable at 4ËšC and 22ËšC but it losses up to 15.03% of its initial concentration when stored for 192 hours at 37 ËšC.

Conclusion: metoclopramide hydrochloride and naloxone hydrochloride admixture is more stable and preferred to ondansetron hydrochloride and naloxone hydrochloride admixture under all storage conditions.

 

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Author Biography

Naser F Altannak, Assistant Professor, Department Of Pharmaceutical Chemistry Faculty Of Pharmacy, Kuwait University, P. O Box 23924, Safat, 13110 Kuwait

PHARMACEUTICAL CHEMISTRY- ASSISTANT PROFESSOR

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Published

01-07-2015

How to Cite

Altannak, N. F. “COMPARATIVE LC-MS STABILITY INDICATIND ASSAYS OF ONDANSETRON HYDROCHLORIDE/NALOXONE HYDROCHLORIDE AND METOCLOPRAMIDE HYDROCHLORIDE/NALOXONE HYDROCHLORIDE USED IN PALLIATIVE CARE”. International Journal of Pharmacy and Pharmaceutical Sciences, vol. 7, no. 7, July 2015, pp. 109-13, https://www.innovareacademics.in/journals/index.php/ijpps/article/view/6064.

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