SIMULTANEOUS ESTIMATION OF FAMOTIDINE AND RABEPRAZOLE SODIUM: METHOD DEVELOPMENT AND VALIDATION BY UV-SPECTROPHOTOMETRIC METHOD

Authors

  • Lenson Paul Dsouza Nitte University, India
  • Marina Koland Nitte University, India

Keywords:

Famotidine, Rabeprazole, Nil, simultaneous estimation

Abstract

Objectives: Study aimed for the simultaneous estimation of Famotidine and Rabeprazole sodium at 263 nm, λmax of Famotidine and 284 nm, λmax of Rabeprazole sodium.

Methods: Method development and validation were done by UV spectrophotometric method.

Results: The method developed obeyed Beer-Lambert's law in the concentration range of 5-30 g/ml for both famotidine and rabeprazole. The results of the analysis have been successfully validated statistically. The %RSD confirms the precision of the proposed method and Recovery studies show the accuracy of the method.

Conclusion: This method was simple, precise and accurate and was successfully applied to the determination of these drugs in the laboratory mixture.

 

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References

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Published

01-07-2015

How to Cite

Dsouza, L. P., and M. Koland. “SIMULTANEOUS ESTIMATION OF FAMOTIDINE AND RABEPRAZOLE SODIUM: METHOD DEVELOPMENT AND VALIDATION BY UV-SPECTROPHOTOMETRIC METHOD”. International Journal of Pharmacy and Pharmaceutical Sciences, vol. 7, no. 7, July 2015, pp. 257-60, https://www.innovareacademics.in/journals/index.php/ijpps/article/view/6223.

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Original Article(s)