INVESTIGATION GENOTOXICITY OF NEW SILVER-BASED COMPLEXWITH ANTIMICROBIAL ACTIVITY

Authors

  • Evgenii Plotnikov Tomsk Polytechnic University, Tomsk, Russia
  • Andrew Gapeyev Institute of Cell Biophysics of Russian Acad. Sci., Pushchino, Russia
  • Vladimir Plotnikov Polytech” ltd, Tomsk, Russia

Keywords:

Geno toxicity, Comet assay, Silver-based complex, Antibacterial drug, Silver hexa-methylene tetramine

Abstract

Objective: Investigation of genotoxicity effects of the new antibacterial silver-based compound with of general formula [Ag (CH2)6 N4]+NO3.

Methods: The comet assay applied for assessment of genotoxic effects on leukocytes of mice blood. DNA damage was assessed on the percentage of DNA in a comet tail (tail DNA), under influence of silver complex in different concentrations.

Results: During experiments found a significant increase in the level of DNA damage in cells, at the maximum tested concentrations. At low doses, the drug has no significant genotoxic effect.

Conclusion: Tested silver complex did not cause DNA damage at low concentrations and could be considered as a base for new antibacterial drug.

 

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References

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Published

01-07-2015

How to Cite

Plotnikov, E., A. Gapeyev, and V. Plotnikov. “INVESTIGATION GENOTOXICITY OF NEW SILVER-BASED COMPLEXWITH ANTIMICROBIAL ACTIVITY”. International Journal of Pharmacy and Pharmaceutical Sciences, vol. 7, no. 7, July 2015, pp. 454-5, https://www.innovareacademics.in/journals/index.php/ijpps/article/view/6227.

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Section

Short Communication(s)